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2015 ; 35
(3
): 266-78
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Morphology in the Digital Age: Integrating High-Resolution Description of
Structural Alterations With Phenotypes and Genotypes
#MMPMID26215864
Nast CC
; Lemley KV
; Hodgin JB
; Bagnasco S
; Avila-Casado C
; Hewitt SM
; Barisoni L
Semin Nephrol
2015[May]; 35
(3
): 266-78
PMID26215864
show ga
Conventional light microscopy has been used to characterize and classify renal
diseases, evaluate histopathology in studies and trials, and educate renal
pathologists and nephrologists. The advent of digital pathology, in which a glass
slide can be scanned to create whole slide images (WSIs) for viewing and
manipulating on a computer monitor, provides real and potential advantages
compared with conventional light microscopy. Software tools such as annotation,
morphometry, and image analysis can be applied to WSIs for studies or educational
purposes, and the digital images are available globally to clinicians,
pathologists, and investigators. New ways of assessing renal pathology with
observational data collection may allow better morphologic correlations and
integration with molecular and genetic signatures, refinements of classification
schema, and understanding of disease pathogenesis. In multicenter studies, WSIs,
which require additional quality assurance steps, provide efficiency by reducing
slide shipping and consensus conference costs, and they allow slide viewing
anytime and anywhere. Although validation studies for the routine diagnostic use
of digital pathology still are needed, this is a powerful tool currently
available for translational research, clinical trials, and education in renal
pathology.