Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/nature14897 http://scihub22266oqcxt.onion/10.1038/nature14897 C4764075!4764075!26331542     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2015 ; 525 (7568): 256-60 Nephropedia Template TP {{tp|p=26331542|t=2015. Distinct EMT programs control normal mammary stem cells and tumour-initiating cells |pdf=|usr=}}{{26331542}} gab.com Text Distinct EMT programs control normal mammary stem cells and tumour-initiating cells JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=26331542 #FOAvip Tumour-initiating cells (TICs) are responsible for metastatic dissemination and clinical relapse in a variety of cancers1,2. Analogies between TICs and normal tissue stem cells have led to the notion that activation of the normal stem-cell program within a tissue serves as the major mechanism for generating TICs3-7. Supporting this notion, we and others previously established that the Slug EMT-TF (EMT-inducing transcription factor), a member of the Snail family, is a master regulator of the gland-reconstituting activity of normal mammary stem cells (MaSCs), and that forced expression of Slug in collaboration with Sox9 in breast cancer cells can efficiently induce entrance into the TIC state8. However, these earlier studies focused on xenograft models with cultured cell lines and involved ectopic expression of EMT-TFs, often at non-physiological levels. Using genetically engineered knock-in reporter mouse lines, here we show that normal gland-reconstituting MaSCs9-11 residing in the basal layer of the mammary epithelium and breast TICs originating in the luminal layer exploit the paralogous EMT-TFs Slug and Snail respectively, which induce in turn distinct EMT programs. Broadly, our findings suggest that the seemingly similar stem-cell programs operating in TICs and normal stem cells of the corresponding normal tissue are likely to differ significantly in their details. Twit Text FOAVip Distinct EMT programs control normal mammary stem cells and tumour-initiating cells ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=26331542 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26331542 #FOAvip English Wikipedia <ref>{{Cite pmid|26331542}}</ref> Distinct EMT programs control normal mammary stem cells and tumour-initiating cells #MMPMID26331542 Ye X; Tam WL; Shibue T; Kaygusuz Y; Reinhardt F; Eaton E; Weinberg RA Nature 2015[Sep]; 525 (7568): 256-60 PMID26331542show ga Tumour-initiating cells (TICs) are responsible for metastatic dissemination and clinical relapse in a variety of cancers1,2. Analogies between TICs and normal tissue stem cells have led to the notion that activation of the normal stem-cell program within a tissue serves as the major mechanism for generating TICs3-7. Supporting this notion, we and others previously established that the Slug EMT-TF (EMT-inducing transcription factor), a member of the Snail family, is a master regulator of the gland-reconstituting activity of normal mammary stem cells (MaSCs), and that forced expression of Slug in collaboration with Sox9 in breast cancer cells can efficiently induce entrance into the TIC state8. However, these earlier studies focused on xenograft models with cultured cell lines and involved ectopic expression of EMT-TFs, often at non-physiological levels. Using genetically engineered knock-in reporter mouse lines, here we show that normal gland-reconstituting MaSCs9-11 residing in the basal layer of the mammary epithelium and breast TICs originating in the luminal layer exploit the paralogous EMT-TFs Slug and Snail respectively, which induce in turn distinct EMT programs. Broadly, our findings suggest that the seemingly similar stem-cell programs operating in TICs and normal stem cells of the corresponding normal tissue are likely to differ significantly in their details. äDistinct EMT programs control normal mammary stem cells and tumour-ini(epmc).pdf DeepDyve Pubget Overpricing