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10.1097/HJH.0000000000000825 http://scihub22266oqcxt.onion/10.1097/HJH.0000000000000825 C4764029!4764029!26771338     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Hypertens 2016 ; 34 (3): 486-94 Nephropedia Template TP {{tp|p=26771338|t=2016. (Pro)renin receptor contributes to regulation of renal epithelial sodium channel |pdf=|usr=}}{{26771338}} gab.com Text (Pro)renin receptor contributes to regulation of renal epithelial sodium channel JO: J Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=26771338 #FOAvip Recent studies reported increased (Pro)renin receptor (PRR) expression during low-salt intake. We hypothesized that PRR plays a role in regulation of renal epithelial sodium channel (ENaC) through serum and glucocorticoid-inducible kinase isoform 1 (SGK-1)-neural precursor cell expressed, developmentally downregulated 4?2 (Nedd4?2) signaling pathway. Male Sprague?Dawley rats on normal-sodium diet and mouse renal inner medullary collecting duct cells treated with NaCl at 130 mmol/l (normal salt), or 63 mmol/l (low salt) were studied. PRR and ?-ENaC expressions were evaluated 1 week after right uninephrectomy and left renal interstitial administration of 5% dextrose, scramble shRNA, or PRR shRNA (n = 6 each treatment). In-vivo PRR shRNA significantly reduced expressions of PRR throughout the kidney and ?-ENaC subunits in the renal medulla. In inner medullary collecting duct cells, low salt or angiopoietin II (Ang II) augmented the mRNA and protein expressions of PRR (P < 0.05), SGK-1 (P < 0.05), and ?-ENaC (P < 0.05). Low salt or Ang II increased the phosphorylation of Nedd4?2. In cells treated with low salt or Ang II, PRR siRNA significantly downregulated the mRNA and protein expressions of PRR (P < 0.05), SGK-1 (P < 0.05), and ?-ENaC expression (P < 0.05). We conclude that PRR contributes to the regulation of ?-ENaC via SGK-1-Nedd4?2 signaling pathway. Twit Text FOAVip (Pro)renin receptor contributes to regulation of renal epithelial sodium channel ????J Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=26771338 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26771338 #FOAvip English Wikipedia <ref>{{Cite pmid|26771338}}</ref> (Pro)renin receptor contributes to regulation of renal epithelial sodium channel #MMPMID26771338 Quadri S; Siragy HM J Hypertens 2016[Mar]; 34 (3): 486-94 PMID26771338show ga Recent studies reported increased (Pro)renin receptor (PRR) expression during low-salt intake. We hypothesized that PRR plays a role in regulation of renal epithelial sodium channel (ENaC) through serum and glucocorticoid-inducible kinase isoform 1 (SGK-1)-neural precursor cell expressed, developmentally downregulated 4?2 (Nedd4?2) signaling pathway. Male Sprague?Dawley rats on normal-sodium diet and mouse renal inner medullary collecting duct cells treated with NaCl at 130 mmol/l (normal salt), or 63 mmol/l (low salt) were studied. PRR and ?-ENaC expressions were evaluated 1 week after right uninephrectomy and left renal interstitial administration of 5% dextrose, scramble shRNA, or PRR shRNA (n = 6 each treatment). In-vivo PRR shRNA significantly reduced expressions of PRR throughout the kidney and ?-ENaC subunits in the renal medulla. In inner medullary collecting duct cells, low salt or angiopoietin II (Ang II) augmented the mRNA and protein expressions of PRR (P < 0.05), SGK-1 (P < 0.05), and ?-ENaC (P < 0.05). Low salt or Ang II increased the phosphorylation of Nedd4?2. In cells treated with low salt or Ang II, PRR siRNA significantly downregulated the mRNA and protein expressions of PRR (P < 0.05), SGK-1 (P < 0.05), and ?-ENaC expression (P < 0.05). We conclude that PRR contributes to the regulation of ?-ENaC via SGK-1-Nedd4?2 signaling pathway. ä(Pro)renin receptor contributes to regulation of renal epithelial sodi(epmc).pdf DeepDyve Pubget Overpricing