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Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Shanghai+Arch+Psychiatry 2015 ; 27 (5): 319-25 Nephropedia Template TP
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The effect of simple imputation on inferences about population means when data are missing in biomedical research due to detection limits #MMPMID26977131
WANG H; CHEN G; LU X; ZHANG H; FENG C
Shanghai Arch Psychiatry 2015[Oct]; 27 (5): 319-25 PMID26977131show ga
The sample geometric mean has been widely used in biomedical and psychosocial research to estimate and compare population geometric means. However, due to the detection limit of measurement instruments, the actual value of the measurement is not always observable. A common practice to deal with this problem is to replace missing values by small positive constants and make inferences based on the imputed data. However, no work has been carried out to study the effect of this naïve imputation method on inference. In this report, we show that this simple imputation method may dramatically change the reported outcomes of a study and, thus, make the results uninterpretable, even if the detection limit is very small.