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10.1371/journal.ppat.1005461 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1005461 C4763345!4763345!26900854     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2016 ; 12 (2): ä Nephropedia Template TP {{tp|p=26900854|t=2016. Surfactant Protein-D Is Essential for Immunity to Helminth Infection |pdf=|usr=}}{{26900854}} gab.com Text Surfactant Protein-D Is Essential for Immunity to Helminth Infection JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=26900854 #FOAvip Pulmonary epithelial cell responses can enhance type 2 immunity and contribute to control of nematode infections. An important epithelial product is the collectin Surfactant Protein D (SP-D). We found that SP-D concentrations increased in the lung following Nippostrongylus brasiliensis infection; this increase was dependent on key components of the type 2 immune response. We carried out loss and gain of function studies of SP-D to establish if SP-D was required for optimal immunity to the parasite. N. brasiliensis infection of SP-D-/- mice resulted in profound impairment of host innate immunity and ability to resolve infection. Raising pulmonary SP-D levels prior to infection enhanced parasite expulsion and type 2 immune responses, including increased numbers of IL-13 producing type 2 innate lymphoid cells (ILC2), elevated expression of markers of alternative activation by alveolar macrophages (alvM) and increased production of the type 2 cytokines IL-4 and IL-13. Adoptive transfer of alvM from SP-D-treated parasite infected mice into naïve recipients enhanced immunity to N. brasiliensis. Protection was associated with selective binding by the SP-D carbohydrate recognition domain (CRD) to L4 parasites to enhance their killing by alvM. These findings are the first demonstration that the collectin SP-D is an essential component of host innate immunity to helminths. Twit Text FOAVip Surfactant Protein-D Is Essential for Immunity to Helminth Infection ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=26900854 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26900854 #FOAvip English Wikipedia <ref>{{Cite pmid|26900854}}</ref> Surfactant Protein-D Is Essential for Immunity to Helminth Infection #MMPMID26900854 Thawer S; Auret J; Schnoeller C; Chetty A; Smith K; Darby M; Roberts L; Mackay RM; Whitwell HJ; Timms JF; Madsen J; Selkirk ME; Brombacher F; Clark HW; Horsnell WGC PLoS Pathog 2016[Feb]; 12 (2): ä PMID26900854show ga Pulmonary epithelial cell responses can enhance type 2 immunity and contribute to control of nematode infections. An important epithelial product is the collectin Surfactant Protein D (SP-D). We found that SP-D concentrations increased in the lung following Nippostrongylus brasiliensis infection; this increase was dependent on key components of the type 2 immune response. We carried out loss and gain of function studies of SP-D to establish if SP-D was required for optimal immunity to the parasite. N. brasiliensis infection of SP-D-/- mice resulted in profound impairment of host innate immunity and ability to resolve infection. Raising pulmonary SP-D levels prior to infection enhanced parasite expulsion and type 2 immune responses, including increased numbers of IL-13 producing type 2 innate lymphoid cells (ILC2), elevated expression of markers of alternative activation by alveolar macrophages (alvM) and increased production of the type 2 cytokines IL-4 and IL-13. Adoptive transfer of alvM from SP-D-treated parasite infected mice into naïve recipients enhanced immunity to N. brasiliensis. Protection was associated with selective binding by the SP-D carbohydrate recognition domain (CRD) to L4 parasites to enhance their killing by alvM. These findings are the first demonstration that the collectin SP-D is an essential component of host innate immunity to helminths. äSurfactant Protein-D Is Essential for Immunity to Helminth Infection (epmc).pdf DeepDyve Pubget Overpricing