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10.1038/srep22151 http://scihub22266oqcxt.onion/10.1038/srep22151 C4763304!4763304 !26903149     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26903149 &cmd=llinks): Failed to open stream: HTTP request failed! 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An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure |pdf=|usr=}}{{26903149 }} gab.com Text An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26903149 #FOAvip Chronic renal failure (CRF) is a major public health problem worldwide. Earlier studies have revealed salutary effects of rhubarb extracts in CRF. In this study, we employed lipidomic and metabolomic approaches to identify the plasma biomarkers and to determine the effect of treatment with petroleum ether, ethyl acetate and n-butanol extracts of rhubarb in a rat model of CRF with adenine-induced chronic tubulointerstitial nephropathy. In addition, clinical biochemistry, histological evaluation and pro-fibrotic protein expression were analyzed. Significant changes were found between the CRF and control groups representing characteristic phenotypes of rats with CRF. Treatment with the three rhubarb extracts improved renal injury and dysfunction, either fully or partially reversed the plasma metabolites abnormalities and attenuated upregulation of pro-fibrotic proteins including TGF-?1, ?-SMA, PAI-1, CTGF, FN and collagen-1. The nephroprotective effect of ethyl acetate extract was better than other extracts. The differential metabolites were closely associated with glycerophospholipid, fatty acid and amino acid metabolisms. The results revealed a strong link between renal tubulointerstitial fibrosis and glycerophospholipid metabolism and L-carnitine metabolism in the development of CRF. Amelioration of CRF with the three rhubarb extracts was associated with the delayed development and/or reversal the disorders in key metabolites associated with adenine-induced CRF. Twit Text FOAVip An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26903149 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26903149 #FOAvip English Wikipedia <ref>{{Cite pmid|26903149 }}</ref> An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure #MMPMID26903149 Zhang ZH ; Vaziri ND ; Wei F ; Cheng XL ; Bai X ; Zhao YY Sci Rep 2016[Feb]; 6 (ä): 22151 PMID26903149 show ga Chronic renal failure (CRF) is a major public health problem worldwide. Earlier studies have revealed salutary effects of rhubarb extracts in CRF. In this study, we employed lipidomic and metabolomic approaches to identify the plasma biomarkers and to determine the effect of treatment with petroleum ether, ethyl acetate and n-butanol extracts of rhubarb in a rat model of CRF with adenine-induced chronic tubulointerstitial nephropathy. In addition, clinical biochemistry, histological evaluation and pro-fibrotic protein expression were analyzed. Significant changes were found between the CRF and control groups representing characteristic phenotypes of rats with CRF. Treatment with the three rhubarb extracts improved renal injury and dysfunction, either fully or partially reversed the plasma metabolites abnormalities and attenuated upregulation of pro-fibrotic proteins including TGF-?1, ?-SMA, PAI-1, CTGF, FN and collagen-1. The nephroprotective effect of ethyl acetate extract was better than other extracts. The differential metabolites were closely associated with glycerophospholipid, fatty acid and amino acid metabolisms. The results revealed a strong link between renal tubulointerstitial fibrosis and glycerophospholipid metabolism and L-carnitine metabolism in the development of CRF. Amelioration of CRF with the three rhubarb extracts was associated with the delayed development and/or reversal the disorders in key metabolites associated with adenine-induced CRF. |*Metabolome [MESH] |Animals [MESH] |Disease Models, Animal [MESH] |Fibrosis/pathology/prevention & control [MESH] |Histocytochemistry [MESH] |Immunohistochemistry [MESH] |Kidney Failure, Chronic/chemically induced/*drug therapy [MESH] |Kidney/pathology [MESH] |Male [MESH] |Plant Extracts/administration & dosage/*pharmacology [MESH] |Plasma/chemistry [MESH] |Rats, Sprague-Dawley [MESH] |Rheum/*chemistry [MESH]An integrated lipidomics and metabolomics reveal nephroprotective effe(epmc).pdf DeepDyve Pubget Overpricing