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10.1038/mi.2015.11 http://scihub22266oqcxt.onion/10.1038/mi.2015.11 C4762901!4762901!25736456     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mucosal+Immunol 2015 ; 8 (6): 1201-11 Nephropedia Template TP {{tp|p=25736456|t=2015. Nuclear matrix binding protein SMAR1 regulates T-cell differentiation and allergic airway disease |pdf=|usr=}}{{25736456}} gab.com Text Nuclear matrix binding protein SMAR1 regulates T-cell differentiation and allergic airway disease JO: Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25736456 #FOAvip Asthma is a complex airway allergic disease involving the interplay of various cell types, cytokines, and transcriptional factors. Though many factors contribute to disease etiology, the molecular control of disease phenotype and responsiveness is not well understood. Here we report an essential role of the matrix attachment region (MAR)-binding protein SMAR1 in regulating immune response during allergic airway disease. Conditional knockout of SMAR1 in T cells rendered the mice resistant to eosinophilic airway inflammation against ovalbumin (OVA) allergen with low immunoglobulin E (IgE) and interleukin-5 (IL-5) levels. Moreover, a lower IgE/IgG2a ratio and higher interferon-? (IFN-?) response suggested aberrant skewing of T-cell differentiation toward type 1 helper T cell (Th1) response. We show that SMAR1 functions as a negative regulator of Th1 and Th17 differentiation by interacting with two potential and similar MAR regions present on the promoters of T-bet and IL-17. Thus, we present SMAR1 as a regulator of T-cell differentiation that favors the establishment of Th2 cells by modulating Th1 and Th17 responses. Twit Text FOAVip Nuclear matrix binding protein SMAR1 regulates T-cell differentiation and allergic airway disease ????Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25736456 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25736456 #FOAvip English Wikipedia <ref>{{Cite pmid|25736456}}</ref> Nuclear matrix binding protein SMAR1 regulates T-cell differentiation and allergic airway disease #MMPMID25736456 Chemmannur SV; Badhwar AJ; Mirlekar B; Malonia SK; Gupta M; Wadhwa N; Bopanna R; Mabalirajan U; Majumdar S; Ghosh B; Chattopadhyay S Mucosal Immunol 2015[Nov]; 8 (6): 1201-11 PMID25736456show ga Asthma is a complex airway allergic disease involving the interplay of various cell types, cytokines, and transcriptional factors. Though many factors contribute to disease etiology, the molecular control of disease phenotype and responsiveness is not well understood. Here we report an essential role of the matrix attachment region (MAR)-binding protein SMAR1 in regulating immune response during allergic airway disease. Conditional knockout of SMAR1 in T cells rendered the mice resistant to eosinophilic airway inflammation against ovalbumin (OVA) allergen with low immunoglobulin E (IgE) and interleukin-5 (IL-5) levels. Moreover, a lower IgE/IgG2a ratio and higher interferon-? (IFN-?) response suggested aberrant skewing of T-cell differentiation toward type 1 helper T cell (Th1) response. We show that SMAR1 functions as a negative regulator of Th1 and Th17 differentiation by interacting with two potential and similar MAR regions present on the promoters of T-bet and IL-17. Thus, we present SMAR1 as a regulator of T-cell differentiation that favors the establishment of Th2 cells by modulating Th1 and Th17 responses. äNuclear matrix binding protein SMAR1 regulates T-cell differentiation (epmc).pdf DeepDyve Pubget Overpricing