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10.1038/ncomms10680 http://scihub22266oqcxt.onion/10.1038/ncomms10680 C4762884!4762884!26893169     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26893169|t=2016. Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses |pdf=|usr=}}{{26893169}} gab.com Text Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26893169 #FOAvip Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses. During infection with DNA viruses STING is activated downstream of cGAMP synthase (cGAS) to induce type I interferon. Here we identify a STING-dependent, cGAS-independent pathway important for full interferon production and antiviral control of enveloped RNA viruses, including influenza A virus (IAV). Further, IAV interacts with STING through its conserved hemagglutinin fusion peptide (FP). Interestingly, FP antagonizes interferon production induced by membrane fusion or IAV but not by cGAMP or DNA. Similar to the enveloped RNA viruses, membrane fusion stimulates interferon production in a STING-dependent but cGAS-independent manner. Abolishment of this pathway led to reduced interferon production and impaired control of enveloped RNA viruses. Thus, enveloped RNA viruses stimulate a cGAS-independent STING pathway, which is targeted by IAV. Twit Text FOAVip Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26893169 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26893169 #FOAvip English Wikipedia <ref>{{Cite pmid|26893169}}</ref> Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses #MMPMID26893169 Holm CK; Rahbek SH; Gad HH; Bak RO; Jakobsen MR; Jiang Z; Hansen AL; Jensen SK; Sun C; Thomsen MK; Laustsen A; Nielsen CG; Severinsen K; Xiong Y; Burdette DL; Hornung V; Lebbink RJ; Duch M; Fitzgerald KA; Bahrami S; Mikkelsen JG; Hartmann R; Paludan SR Nat Commun 2016[]; 7 (ä): ä PMID26893169show ga Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses. During infection with DNA viruses STING is activated downstream of cGAMP synthase (cGAS) to induce type I interferon. Here we identify a STING-dependent, cGAS-independent pathway important for full interferon production and antiviral control of enveloped RNA viruses, including influenza A virus (IAV). Further, IAV interacts with STING through its conserved hemagglutinin fusion peptide (FP). Interestingly, FP antagonizes interferon production induced by membrane fusion or IAV but not by cGAMP or DNA. Similar to the enveloped RNA viruses, membrane fusion stimulates interferon production in a STING-dependent but cGAS-independent manner. Abolishment of this pathway led to reduced interferon production and impaired control of enveloped RNA viruses. Thus, enveloped RNA viruses stimulate a cGAS-independent STING pathway, which is targeted by IAV. äInfluenza A virus targets a cGAS-independent STING pathway that contro(epmc).pdf DeepDyve Pubget Overpricing