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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Ophthalmol
2016 ; 9
(2
): 286-91
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Multifocal electroretinogram in non-pathological myopic subjects: correlation
with optical coherence tomography
#MMPMID26949653
Song AP
; Yu T
; Wang JR
; Liu W
; Sun Y
; Ma SX
Int J Ophthalmol
2016[]; 9
(2
): 286-91
PMID26949653
show ga
AIM: To investigate the changes of retinal function in non-pathological myopic
subjects using multifocal electroretinography (mfERG) and to correlate the data
with the central macular thickness obtained using optical coherence tomography
(OCT). METHODS: One hundred and thirteen subjects (113 eyes) with age range from
18 to 35y were enrolled in the study. The subjects were divided into four groups
according to spherical equivalent (SE) and axial length (AL): emmetropia group
(EG, n=31; SE: +0.75 to -0.50 D; AL: 22 to 24 mm), low and medium myopia group
(LMMG, n=26; SE: >-0.50 to -6.00 D; AL: >24 to 26 mm), high myopia group (HMG,
n=34; SE: >-6.00 to -10.00 D; AL: >26 to 28 mm) and super high myopia group
(SHMG, n=22; SE: >-10.00 D; AL:>28 mm). The P1 amplitude density, P1 amplitude,
and P1 implicit time of the first-order kernel mfERG responses were obtained and
grouped into five rings. The central subfield macular thickness (CST) was
obtained using macular cube 512×218 scan of Cirrus HD-OCT. RESULTS: With the
increasing of eccentricity, the first positive peak (P1) amplitude density
(P=0.0000, 0.0001, 0.0021 in ring 1-3 respectively) and P1 amplitude (all
P=0.0000 in ring 1-5) of each group decreased. With the increasing of myopia, P1
implicit time gradually extended (all P=0.0000 in ring 1-3). The average CST in
four diagnostic groups was 241.56±12.72 µm, 244.56±12.19 µm, 254.33±11.61 µm,
261.75±11.83 µm respectively. With the increasing of myopia, CST increased
(P<0.001). There was negative relationship between CST and P1 amplitude, P1
amplitude density (r=-0.402, P<0.001; r=-0.261, P=0.003). There was positive
relationship between CST and P1 implicit time (r=0.34, P<0.001). CONCLUSION: With
the increasing of myopia, P1 amplitude density and P1 amplitude of the
first-order reaction gradually reduced. This showed potential decline in retinal
function in myopia. To some extent it may reflect the functional disorder or
depression of the visual cells. The exact mechanism needs further study.