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10.2174/1570159X13666150630171954

http://scihub22266oqcxt.onion/10.2174/1570159X13666150630171954
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C4761631!4761631!26467409
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suck abstract from ncbi


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pmid26467409      Curr+Neuropharmacol 2015 ; 13 (5): 592-604
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  • Pharmacological Approaches for Treatment-resistant Bipolar Disorder #MMPMID26467409
  • Poon SH; Sim K; Baldessarini RJ
  • Curr Neuropharmacol 2015[Sep]; 13 (5): 592-604 PMID26467409show ga
  • Bipolar disorder is prevalent, with high risks of disability, substance abuse and premature mortality. Treatment responses typically are incomplete, especially for depressive components, so that many cases can be considered ?treatment resistant.? We reviewed reports on experimental treatments for such patients: there is a striking paucity of such research, mainly involving small incompletely controlled trials of add-on treatment, and findings remain preliminary. Encouraging results have been reported by adding aripiprazole, bupropion, clozapine, ketamine, memantine, pramipexole, pregabalin, and perhaps tri-iodothyronine in resistant manic or depressive phases. The urgency of incomplete responses in such a severe illness underscores the need for more systematic, simpler, and better controlled studies in more homogeneous samples of patients.
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