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10.1111/febs.13472

http://scihub22266oqcxt.onion/10.1111/febs.13472
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C4761532!4761532!26293580
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suck abstract from ncbi


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pmid26293580      FEBS+J 2016 ; 283 (14): 2661-75
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  • Attacking Cancer?s Achilles Heel: Antagonism of Anti-Apoptotic BCL-2 Family Members #MMPMID26293580
  • Opferman JT
  • FEBS J 2016[Jul]; 283 (14): 2661-75 PMID26293580show ga
  • Malignant cells routinely violate cellular checkpoints that should initiate cell death in normal cells by triggering pro-apoptotic members of the BCL-2 family of proteins. To escape such death inducing signals, cancer cells often select for up regulation of anti-apoptotic BCL-2 family members including BCL-2, BCL-XL, BFL-1, BCL-W, and MCL-1. These family members prevent death by sequestering pro-apoptotic molecules. To counter this resistance mechanism, small molecule inhibitors of anti-apoptotic BCL-2 family members have been under development. These molecules have shown promise in pre-clinical and clinical testing to overcome apoptotic resistance, prompting cancer cells to undergo apoptosis. Alternatively, other strategies have taken advantage of the normal regulatory machinery controlling anti-apoptotic molecules and have used inhibitors of signaling pathways to down-modulate the expression of anti-apoptotic molecules thus tilting the balance in cancer cells to cell death. This review explores recent developments and strategies aimed at antagonizing anti-apoptotic BCL-2 family member action to promote the induction of cell death in cancer therapy.
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