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10.4049/jimmunol.1501557 http://scihub22266oqcxt.onion/10.4049/jimmunol.1501557 C4761472!4761472!26826244     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 196 (5): 2004-9 Nephropedia Template TP {{tp|p=26826244|t=2016. Critical Role of Glycolysis in Human Plasmacytoid Dendritic Cell Antiviral Responses |pdf=|usr=}}{{26826244}} gab.com Text Critical Role of Glycolysis in Human Plasmacytoid Dendritic Cell Antiviral Responses JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26826244 #FOAvip Plasmacytoid dendritic cells (pDCs) are vital to antiviral defense, directing immune responses via secretion of huge concentrations of IFN-?. These cells are critical in protecting the lung against clinically relevant respiratory viruses, particularly influenza (Flu), a virus responsible for substantial worldwide morbidity and mortality. How pDC responses to such viral pathogens are regulated, however, is poorly understood in humans. Using an unbiased approach of gene chip analysis, we discovered that Flu significantly impacts metabolism in primary human pDCs. We demonstrate that Flu and RV, another common respiratory virus, induce glycolysis in pDCs and that this metabolic pathway regulates pDC antiviral functions including IFN-? production and phenotypic maturation. Intranasal vaccination of human volunteers with live influenza virus also increases glycolysis in circulating pDCs, highlighting a previously unrecognized potential role for metabolism in regulating pDC immune responses to viral infections in humans. Twit Text FOAVip Critical Role of Glycolysis in Human Plasmacytoid Dendritic Cell Antiviral Responses ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26826244 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26826244 #FOAvip English Wikipedia <ref>{{Cite pmid|26826244}}</ref> Critical Role of Glycolysis in Human Plasmacytoid Dendritic Cell Antiviral Responses #MMPMID26826244 Bajwa G; DeBerardinis RJ; Shao B; Hall B; Farrar JD; Gill MA J Immunol 2016[Mar]; 196 (5): 2004-9 PMID26826244show ga Plasmacytoid dendritic cells (pDCs) are vital to antiviral defense, directing immune responses via secretion of huge concentrations of IFN-?. These cells are critical in protecting the lung against clinically relevant respiratory viruses, particularly influenza (Flu), a virus responsible for substantial worldwide morbidity and mortality. How pDC responses to such viral pathogens are regulated, however, is poorly understood in humans. Using an unbiased approach of gene chip analysis, we discovered that Flu significantly impacts metabolism in primary human pDCs. We demonstrate that Flu and RV, another common respiratory virus, induce glycolysis in pDCs and that this metabolic pathway regulates pDC antiviral functions including IFN-? production and phenotypic maturation. Intranasal vaccination of human volunteers with live influenza virus also increases glycolysis in circulating pDCs, highlighting a previously unrecognized potential role for metabolism in regulating pDC immune responses to viral infections in humans. äCritical Role of Glycolysis in Human Plasmacytoid Dendritic Cell Antiv(epmc).pdf DeepDyve Pubget Overpricing