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10.4049/jimmunol.1501877 http://scihub22266oqcxt.onion/10.4049/jimmunol.1501877 C4761465!4761465!26810223     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 196 (5): 2145-52 Nephropedia Template TP {{tp|p=26810223|t=2016. PTPN22 modifies regulatory T cell homeostasis via GITR upregulation |pdf=|usr=}}{{26810223}} gab.com Text PTPN22 modifies regulatory T cell homeostasis via GITR upregulation JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26810223 #FOAvip PTPN22 gene variation associates with multiple autoimmune diseases including type 1 diabetes and rheumatoid arthritis. Loss of function studies have demonstrated that PTPN22 impinges on the homeostatic behavior of regulatory T (Treg) cells, a lineage critical for immune tolerance. The frequency and absolute number of Treg cells is increased in Ptpn22 deficient mice, but the mechanism driving this increase is unknown. We show here that Ptpn22 knockdown (KD) promoted the expansion of the Treg cell compartment by up-regulating the glucocorticoid-induced TNF receptor family-related protein (GITR) and increasing GITR signaling. Ptpn22 KD did not accelerate cell division but instead prolonged Treg cell survival, as measured by a decrease in the frequency of apoptotic Treg cells. Loss of Ptpn22 caused a concomitant increase in the proportion of CD44hiCD62Llo ?effector? Treg cells, at the expense of CD44loCD62Lhi ?central? Treg cells. The increase in Treg cell numbers, but not their differentiation towards an effector phenotype, was dependent on GITR signaling, because blockade of GITR-L prevented Treg cell expansion caused by Ptpn22 KD. These findings indicate that GITR plays a key role in regulating the overall size of the Treg cell pool. Our results suggest that the size and composition of the Treg cell compartment are independently controlled, and have implications for the design of immunotherapies that seek to improve Treg cell function. Twit Text FOAVip PTPN22 modifies regulatory T cell homeostasis via GITR upregulation ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26810223 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26810223 #FOAvip English Wikipedia <ref>{{Cite pmid|26810223}}</ref> PTPN22 modifies regulatory T cell homeostasis via GITR upregulation #MMPMID26810223 Nowakowska DJ; Kissler S J Immunol 2016[Mar]; 196 (5): 2145-52 PMID26810223show ga PTPN22 gene variation associates with multiple autoimmune diseases including type 1 diabetes and rheumatoid arthritis. Loss of function studies have demonstrated that PTPN22 impinges on the homeostatic behavior of regulatory T (Treg) cells, a lineage critical for immune tolerance. The frequency and absolute number of Treg cells is increased in Ptpn22 deficient mice, but the mechanism driving this increase is unknown. We show here that Ptpn22 knockdown (KD) promoted the expansion of the Treg cell compartment by up-regulating the glucocorticoid-induced TNF receptor family-related protein (GITR) and increasing GITR signaling. Ptpn22 KD did not accelerate cell division but instead prolonged Treg cell survival, as measured by a decrease in the frequency of apoptotic Treg cells. Loss of Ptpn22 caused a concomitant increase in the proportion of CD44hiCD62Llo ?effector? Treg cells, at the expense of CD44loCD62Lhi ?central? Treg cells. The increase in Treg cell numbers, but not their differentiation towards an effector phenotype, was dependent on GITR signaling, because blockade of GITR-L prevented Treg cell expansion caused by Ptpn22 KD. These findings indicate that GITR plays a key role in regulating the overall size of the Treg cell pool. Our results suggest that the size and composition of the Treg cell compartment are independently controlled, and have implications for the design of immunotherapies that seek to improve Treg cell function. äPTPN22 modifies regulatory T cell homeostasis via GITR upregulation (epmc).pdf DeepDyve Pubget Overpricing