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10.4049/jimmunol.1501690 http://scihub22266oqcxt.onion/10.4049/jimmunol.1501690 C4761464!4761464!26810226     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 196 (5): 2195-204 Nephropedia Template TP {{tp|p=26810226|t=2016. Essential role for survivin in the proliferative expansion of progenitor and mature B cells1 |pdf=|usr=}}{{26810226}} gab.com Text Essential role for survivin in the proliferative expansion of progenitor and mature B cells1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26810226 #FOAvip Survivin is a member of the inhibitor of apoptosis family of proteins and a biomarker of poor prognosis in aggressive B cell non-Hodgkin?s lymphoma (B-NHL). In addition to its role in inhibition of apoptosis, survivin also regulates mitosis. Here, we show that deletion of survivin during early B cell development results in a complete block at the cycling pre-B stage. In the periphery, B cell homeostasis is not affected, but survivin-deficient B cells are unable to mount humoral responses. Correspondingly, we show that survivin is required for cell division in response to mitogenic stimulation. Thus, survivin is essential for proliferation of B cell progenitors and activated mature B cells, but is dispensable for B cell survival. Moreover, a small molecule inhibitor of survivin strongly impaired the growth of representative B lymphoma lines in vitro, support the validity of survivin as an attractive therapeutic target for high-grade B-NHL. Twit Text FOAVip Essential role for survivin in the proliferative expansion of progenitor and mature B cells1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26810226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26810226 #FOAvip English Wikipedia <ref>{{Cite pmid|26810226}}</ref> Essential role for survivin in the proliferative expansion of progenitor and mature B cells1 #MMPMID26810226 Miletic AV; Jellusova J; Cato MH; Lee CR; Baracho GV; Conway EM; Rickert RC J Immunol 2016[Mar]; 196 (5): 2195-204 PMID26810226show ga Survivin is a member of the inhibitor of apoptosis family of proteins and a biomarker of poor prognosis in aggressive B cell non-Hodgkin?s lymphoma (B-NHL). In addition to its role in inhibition of apoptosis, survivin also regulates mitosis. Here, we show that deletion of survivin during early B cell development results in a complete block at the cycling pre-B stage. In the periphery, B cell homeostasis is not affected, but survivin-deficient B cells are unable to mount humoral responses. Correspondingly, we show that survivin is required for cell division in response to mitogenic stimulation. Thus, survivin is essential for proliferation of B cell progenitors and activated mature B cells, but is dispensable for B cell survival. Moreover, a small molecule inhibitor of survivin strongly impaired the growth of representative B lymphoma lines in vitro, support the validity of survivin as an attractive therapeutic target for high-grade B-NHL. äEssential role for survivin in the proliferative expansion of progenit(epmc).pdf DeepDyve Pubget Overpricing