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10.1016/j.cellimm.2015.10.001 http://scihub22266oqcxt.onion/10.1016/j.cellimm.2015.10.001 C4761281!4761281!26454643     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Immunol 2016 ; 301 (ä): 18-29 Nephropedia Template TP {{tp|p=26454643|t=2016. In vivo Induction of Regulatory T Cells for Immune Tolerance in Hemophilia |pdf=|usr=}}{{26454643}} gab.com Text In vivo Induction of Regulatory T Cells for Immune Tolerance in Hemophilia JO: Cell Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26454643 #FOAvip Current therapy for the X-linked coagulation disorder hemophilia is based on intravenous infusion of the specifically deficient coagulation factor. However, 20?30% of hemophilia A patients (factor VIII, FVIII, deficiency) generate inhibitory antibodies against FVIII. Whilst formation of inhibitors directed against factor IX, FIX, resulting from hemophilia B treatment is comparatively rare, a serious complication that is often associated with additional immunotoxicities, e.g. anaphylaxis, occurs. Current immune tolerance protocols to eradiate inhibitors are lengthy, expensive, not effective in all patients, and there are no prophylactic tolerance regimens to prevent inhibitor formation. The outcomes of recent experiments in animal models of hemophilia demonstrate that regulatory CD4+ T cells (Treg) are of paramount importance in controlling B cell responses to FVIII and FIX. This article reviews several novel strategies designed to in vivo induce coagulation factor-specific Treg cells and discusses the subsets of Treg that may promote immune tolerance in hemophilia. Among others, drug- and gene transfer-based protocols, lymphocyte transplant, and oral tolerance are reviewed. Twit Text FOAVip In vivo Induction of Regulatory T Cells for Immune Tolerance in Hemophilia ????Cell Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26454643 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26454643 #FOAvip English Wikipedia <ref>{{Cite pmid|26454643}}</ref> In vivo Induction of Regulatory T Cells for Immune Tolerance in Hemophilia #MMPMID26454643 Wang X; Terhorst C; Herzog RW Cell Immunol 2016[Mar]; 301 (ä): 18-29 PMID26454643show ga Current therapy for the X-linked coagulation disorder hemophilia is based on intravenous infusion of the specifically deficient coagulation factor. However, 20?30% of hemophilia A patients (factor VIII, FVIII, deficiency) generate inhibitory antibodies against FVIII. Whilst formation of inhibitors directed against factor IX, FIX, resulting from hemophilia B treatment is comparatively rare, a serious complication that is often associated with additional immunotoxicities, e.g. anaphylaxis, occurs. Current immune tolerance protocols to eradiate inhibitors are lengthy, expensive, not effective in all patients, and there are no prophylactic tolerance regimens to prevent inhibitor formation. The outcomes of recent experiments in animal models of hemophilia demonstrate that regulatory CD4+ T cells (Treg) are of paramount importance in controlling B cell responses to FVIII and FIX. This article reviews several novel strategies designed to in vivo induce coagulation factor-specific Treg cells and discusses the subsets of Treg that may promote immune tolerance in hemophilia. Among others, drug- and gene transfer-based protocols, lymphocyte transplant, and oral tolerance are reviewed. äIn vivo Induction of Regulatory T Cells for Immune Tolerance in Hemoph(epmc).pdf DeepDyve Pubget Overpricing