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10.1007/s00412-015-0525-x http://scihub22266oqcxt.onion/10.1007/s00412-015-0525-x C4761001!4761001!26198462     free     free     free       Chromosoma 2016 ; 125 (ä): 41-50 Nephropedia Template TP {{tp|p=26198462|t=2016. Cis- and trans-regulation in X inactivation |pdf=|usr=}}{{26198462}} gab.com Text Cis- and trans-regulation in X inactivation JO: Chromosoma http://www.kidney.de/pget.php?&tw=1&pmid=26198462 #FOAvip Female mammalian cells compensate dosage of X-linked gene expression through the inactivation of one of their two X chromosomes. X chromosome inactivation (XCI) in eutherians is dependent on the non-coding RNA Xist that is up-regulated from the future inactive X chromosome, coating it and recruiting factors involved in silencing and altering its chromatin state. Xist lies within the X-inactivation center (Xic), a region on the X that is required for XCI, and is regulated in cis by elements on the X chromosome and in trans by diffusible factors. In this review, we summarize the latest results in cis- and trans-regulation of the Xic. We discuss how the organization of the Xic in topologically associating domains is important for XCI (cis-regulation) and how proteins in the pluripotent state and upon development or differentiation of embryonic stem cells control proper inactivation of one X chromosome (trans-regulation). Twit Text FOAVip Cis- and trans-regulation in X inactivation ????Chromosoma http://www.kidney.de/pget.php?&tw=1&pmid=26198462 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26198462 #FOAvip English Wikipedia <ref>{{Cite pmid|26198462}}</ref> Cis- and trans-regulation in X inactivation #MMPMID26198462 van Bemmel JG; Mira-Bontenbal H; Gribnau J Chromosoma 2016[]; 125 (ä): 41-50 PMID26198462show ga Female mammalian cells compensate dosage of X-linked gene expression through the inactivation of one of their two X chromosomes. X chromosome inactivation (XCI) in eutherians is dependent on the non-coding RNA Xist that is up-regulated from the future inactive X chromosome, coating it and recruiting factors involved in silencing and altering its chromatin state. Xist lies within the X-inactivation center (Xic), a region on the X that is required for XCI, and is regulated in cis by elements on the X chromosome and in trans by diffusible factors. In this review, we summarize the latest results in cis- and trans-regulation of the Xic. We discuss how the organization of the Xic in topologically associating domains is important for XCI (cis-regulation) and how proteins in the pluripotent state and upon development or differentiation of embryonic stem cells control proper inactivation of one X chromosome (trans-regulation). äCis- and trans-regulation in X inactivation (epmc).pdf DeepDyve Pubget Overpricing