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10.1242/jcs.178285 http://scihub22266oqcxt.onion/10.1242/jcs.178285 C4760305!4760305!26675235     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Sci 2016 ; 129 (3): 592-603 Nephropedia Template TP {{tp|p=26675235|t=2016. Interaction between MyRIP and the actin cytoskeleton regulates Weibel?Palade body trafficking and exocytosis |pdf=|usr=}}{{26675235}} gab.com Text Interaction between MyRIP and the actin cytoskeleton regulates Weibel Palade body trafficking and exocytosis JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26675235 #FOAvip Weibel?Palade body (WPB)?actin interactions are essential for the trafficking and secretion of von Willebrand factor; however, the molecular basis for this interaction remains poorly defined. Myosin Va (MyoVa or MYO5A) is recruited to WPBs by a Rab27A?MyRIP complex and is thought to be the prime mediator of actin binding, but direct MyRIP?actin interactions can also occur. To evaluate the specific contribution of MyRIP?actin and MyRIP?MyoVa binding in WPB trafficking and Ca2+-driven exocytosis, we used EGFP?MyRIP point mutants with disrupted MyoVa and/or actin binding and high-speed live-cell fluorescence microscopy. We now show that the ability of MyRIP to restrict WPB movement depends upon its actin-binding rather than its MyoVa-binding properties. We also show that, although the role of MyRIP in Ca2+-driven exocytosis requires both MyoVa- and actin-binding potential, it is the latter that plays a dominant role. In view of these results and together with the analysis of actin disruption or stabilisation experiments, we propose that the role of MyRIP in regulating WPB trafficking and exocytosis is mediated largely through its interaction with actin rather than with MyoVa. Twit Text FOAVip Interaction between MyRIP and the actin cytoskeleton regulates Weibel Palade body trafficking and exocytosis ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=26675235 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26675235 #FOAvip English Wikipedia <ref>{{Cite pmid|26675235}}</ref> Interaction between MyRIP and the actin cytoskeleton regulates Weibel?Palade body trafficking and exocytosis #MMPMID26675235 Conte IL; Hellen N; Bierings R; Mashanov GI; Manneville JB; Kiskin NI; Hannah MJ; Molloy JE; Carter T J Cell Sci 2016[Feb]; 129 (3): 592-603 PMID26675235show ga Weibel?Palade body (WPB)?actin interactions are essential for the trafficking and secretion of von Willebrand factor; however, the molecular basis for this interaction remains poorly defined. Myosin Va (MyoVa or MYO5A) is recruited to WPBs by a Rab27A?MyRIP complex and is thought to be the prime mediator of actin binding, but direct MyRIP?actin interactions can also occur. To evaluate the specific contribution of MyRIP?actin and MyRIP?MyoVa binding in WPB trafficking and Ca2+-driven exocytosis, we used EGFP?MyRIP point mutants with disrupted MyoVa and/or actin binding and high-speed live-cell fluorescence microscopy. We now show that the ability of MyRIP to restrict WPB movement depends upon its actin-binding rather than its MyoVa-binding properties. We also show that, although the role of MyRIP in Ca2+-driven exocytosis requires both MyoVa- and actin-binding potential, it is the latter that plays a dominant role. In view of these results and together with the analysis of actin disruption or stabilisation experiments, we propose that the role of MyRIP in regulating WPB trafficking and exocytosis is mediated largely through its interaction with actin rather than with MyoVa. äInteraction between MyRIP and the actin cytoskeleton regulates Weibel?(epmc).pdf DeepDyve Pubget Overpricing