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2016 ; 5
(ä): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Recent advances in the understanding of endometriosis: the role of inflammatory
mediators in disease pathogenesis and treatment
#MMPMID26949527
Nothnick W
; Alali Z
F1000Res
2016[]; 5
(ä): ä PMID26949527
show ga
In this review, we focus on recent advancements in our understanding of the roles
of inflammatory mediators in endometriosis pathophysiology and the potential for
improved therapies based upon targeting these pathways. We review the association
between endometriosis and inflammation and the initial promise of anti-tumor
necrosis factor therapies based upon experimental evidence, and how and why these
studies have not translated to the clinic. We then discuss emerging data on the
role of inter-relationship among macrophage migration inhibitory factor,
prostaglandin E 2, and estrogen receptor-beta, and the potential utility of
targeting these factors in endometriosis treatment. In doing so, we highlight the
strengths and discuss the current research on identification of novel,
anti-inflammatory-based therapy and the necessity to expand experimental
endpoints to include clinically relevant measures when assessing the efficacy of
potential new therapies for endometriosis.