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10.1080/2159256X.2015.1096998 http://scihub22266oqcxt.onion/10.1080/2159256X.2015.1096998 C4760211!4760211!26942045     free     free     free       Mob+Genet+Elements 2015 ; 5 (6): 92-7 Nephropedia Template TP {{tp|p=26942045|t=2015. LINE retrotransposition and host DNA repair machinery |pdf=|usr=}}{{26942045}} gab.com Text LINE retrotransposition and host DNA repair machinery JO: Mob Genet Elements http://www.kidney.de/pget.php?&tw=1&pmid=26942045 #FOAvip Long interspersed elements (LINEs), or non-long-terminal repeat (LTR) retrotransposons, are mobile genetic elements that exist in the genomic DNA of most eukaryotes, comprising a considerable portion of the host chromosomes. LINEs constitute endogenous mutagens that cause insertional mutations in host chromosomes and have a large impact on host genome evolution. Despite their importance, however, the molecular mechanism of LINE retrotransposition is not fully understood. Several studies suggest that host proteins that participate in the repair of DNA breaks modulate LINE retrotransposition. Recently, we provided evidence that there are 2 distinct pathways?annealing and direct?that join the 5?-end of LINEs to host chromosomal DNA. These pathways appear to be used distinctively by zebrafish LINEs and the human L1 in DT40 cells. In HeLa cells, only the annealing pathway appears to be used. This implies that different characteristics of the 2 LINEs and also host factors dictate which pathway is selected. Here, we discuss the 5?-end-joining pathways of LINE retrotransposition and propose that the pathways of LINE integration adopt certain host repair factors. Twit Text FOAVip LINE retrotransposition and host DNA repair machinery ????Mob Genet Elements http://www.kidney.de/pget.php?&tw=1&pmid=26942045 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26942045 #FOAvip English Wikipedia <ref>{{Cite pmid|26942045}}</ref> LINE retrotransposition and host DNA repair machinery #MMPMID26942045 Yamaguchi K; Kajikawa M; Okada N Mob Genet Elements 2015[Nov]; 5 (6): 92-7 PMID26942045show ga Long interspersed elements (LINEs), or non-long-terminal repeat (LTR) retrotransposons, are mobile genetic elements that exist in the genomic DNA of most eukaryotes, comprising a considerable portion of the host chromosomes. LINEs constitute endogenous mutagens that cause insertional mutations in host chromosomes and have a large impact on host genome evolution. Despite their importance, however, the molecular mechanism of LINE retrotransposition is not fully understood. Several studies suggest that host proteins that participate in the repair of DNA breaks modulate LINE retrotransposition. Recently, we provided evidence that there are 2 distinct pathways?annealing and direct?that join the 5?-end of LINEs to host chromosomal DNA. These pathways appear to be used distinctively by zebrafish LINEs and the human L1 in DT40 cells. In HeLa cells, only the annealing pathway appears to be used. This implies that different characteristics of the 2 LINEs and also host factors dictate which pathway is selected. Here, we discuss the 5?-end-joining pathways of LINE retrotransposition and propose that the pathways of LINE integration adopt certain host repair factors. äLINE retrotransposition and host DNA repair machinery (epmc).pdf DeepDyve Pubget Overpricing