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2016 ; 23
(1
): 27-37
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gab.com Text
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English Wikipedia
Management of Neovascular Age-related Macular Degeneration: A Review on Landmark
Randomized Controlled Trials
#MMPMID26957836
Agarwal A
; Aggarwal K
; Gupta V
Middle East Afr J Ophthalmol
2016[Jan]; 23
(1
): 27-37
PMID26957836
show ga
In the last decade, a number of prospective clinical trials with carefully
designed study protocols have been conducted for the treatment of neovascular
age-related macular degeneration (AMD). These landmark clinical trials such as
ANCHOR and MARINA and, more recently, the Comparison of AMD Treatment Trials and
VIEW studies have revolutionized the management of neovascular AMD. While AMD
continues to remain a leading cause of severe visual loss worldwide, advances in
pharmacotherapeutics have led to substantial improvements in the outcome of these
patients. The introduction of anti-vascular endothelial growth factor agents has
resulted in improvement of visual outcomes and has had a positive impact on the
quality of life among elderly population. While the contemporary management of
neovascular AMD has been successful in tremendously reducing the visual
morbidity, the financial burden of therapy has increased exponentially. To
overcome these challenges, newer pharmacologic agents are evaluated for their
efficacy and safety in AMD. Ground-breaking advances in bench to bedside research
have led to discovery of new pathways that appear to be viable targets for
preventing visual loss in AMD. In this review, study designs and results of
landmark clinical trials in AMD from the past decade have been summarized.
|*Randomized Controlled Trials as Topic
[MESH]
|Angiogenesis Inhibitors/*therapeutic use
[MESH]
|Bevacizumab/therapeutic use
[MESH]
|Humans
[MESH]
|Intravitreal Injections
[MESH]
|Quality of Life/psychology
[MESH]
|Ranibizumab/therapeutic use
[MESH]
|Receptors, Vascular Endothelial Growth Factor/therapeutic use
[MESH]
|Recombinant Fusion Proteins/therapeutic use
[MESH]