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10.1111/jcmm.12745 http://scihub22266oqcxt.onion/10.1111/jcmm.12745 C4759472!4759472!26756858     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2016 ; 20 (3): 549-58 Nephropedia Template TP {{tp|p=26756858|t=2016. Alpha fetoprotein plays a critical role in promoting metastasis of hepatocellular carcinoma cells |pdf=|usr=}}{{26756858}} gab.com Text Alpha fetoprotein plays a critical role in promoting metastasis of hepatocellular carcinoma cells JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26756858 #FOAvip A high level of serum alpha fetoprotein (AFP) is positively associated with human hepatocellular carcinoma (HCC) carcinogenesis and metastasis; however, the function of AFP in HCC metastasis is unknown. This study has explored the effects of AFP on regulating metastatic and invasive capacity of human HCC cells. Forty?seven clinical patients' liver samples were collected and diagnosed; HCC cells line, Bel 7402 cells (AFP?producing) and liver cancer cell line cells (non?AFP?producing) were selected to analyse the role of AFP in the metastasis of HCC cells. The results indicated that high serum concentration of AFP was positively correlated with HCC intrahepatic, lymph nodes and lung metastasis. Repressed expression of AFP significantly inhibited the capability of migration and invasion of Bel 7402 cells, expression of keratin 19 (K19), epithelial cell adhesion molecule (EpCAM), matrix metalloproteinase 2/9 (MMP2/9) and CXC chemokine receptor 4 (CXCR4) were also down?regulated in Bel 7402 cells; migration and invasion, expression of K19, EpCAM, MMP2/9 and CXCR4 were significantly enhanced when HLE cells were transfected with AFP?expressed vector. The results demonstrated that AFP plays a critical role in promoting metastasis of HCC; AFP promoted HCC cell invasion and metastasis via up?regulating expression of metastasis?related proteins. Thus, AFP may be used as a novel therapeutic target for treating HCC patients. Twit Text FOAVip Alpha fetoprotein plays a critical role in promoting metastasis of hepatocellular carcinoma cells ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26756858 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26756858 #FOAvip English Wikipedia <ref>{{Cite pmid|26756858}}</ref> Alpha fetoprotein plays a critical role in promoting metastasis of hepatocellular carcinoma cells #MMPMID26756858 Lu Y; Zhu M; Li W; Lin B; Dong X; Chen Y; Xie X; Guo J; Li M J Cell Mol Med 2016[Mar]; 20 (3): 549-58 PMID26756858show ga A high level of serum alpha fetoprotein (AFP) is positively associated with human hepatocellular carcinoma (HCC) carcinogenesis and metastasis; however, the function of AFP in HCC metastasis is unknown. This study has explored the effects of AFP on regulating metastatic and invasive capacity of human HCC cells. Forty?seven clinical patients' liver samples were collected and diagnosed; HCC cells line, Bel 7402 cells (AFP?producing) and liver cancer cell line cells (non?AFP?producing) were selected to analyse the role of AFP in the metastasis of HCC cells. The results indicated that high serum concentration of AFP was positively correlated with HCC intrahepatic, lymph nodes and lung metastasis. Repressed expression of AFP significantly inhibited the capability of migration and invasion of Bel 7402 cells, expression of keratin 19 (K19), epithelial cell adhesion molecule (EpCAM), matrix metalloproteinase 2/9 (MMP2/9) and CXC chemokine receptor 4 (CXCR4) were also down?regulated in Bel 7402 cells; migration and invasion, expression of K19, EpCAM, MMP2/9 and CXCR4 were significantly enhanced when HLE cells were transfected with AFP?expressed vector. The results demonstrated that AFP plays a critical role in promoting metastasis of HCC; AFP promoted HCC cell invasion and metastasis via up?regulating expression of metastasis?related proteins. Thus, AFP may be used as a novel therapeutic target for treating HCC patients. äAlpha fetoprotein plays a critical role in promoting metastasis of hep(epmc).pdf DeepDyve Pubget Overpricing