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10.1038/mp.2015.18 http://scihub22266oqcxt.onion/10.1038/mp.2015.18 C4759206!4759206!25802982     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Psychiatry 2016 ; 21 (3): 364-75 Nephropedia Template TP {{tp|p=25802982|t=2016. Arc expression identifies the lateral amygdala fear memory trace |pdf=|usr=}}{{25802982}} gab.com Text Arc expression identifies the lateral amygdala fear memory trace JO: Mol Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=25802982 #FOAvip Memories are encoded within sparsely distributed neuronal ensembles. However, the defining cellular properties of neurons within a memory trace remain incompletely understood. Using a fluorescence-based Arc reporter, we were able to visually identify the distinct subset of lateral amygdala (LA) neurons activated during auditory fear conditioning. We found that Arc-expressing neurons have enhanced intrinsic excitability and are preferentially recruited into newly encoded memory traces. Furthermore, synaptic potentiation of thalamic inputs to the LA during fear conditioning is learning-specific, postsynaptically mediated and highly localized to Arc-expressing neurons. Taken together, our findings validate the immediate-early gene Arc as a molecular marker for the LA neuronal ensemble recruited during fear learning. Moreover, these results establish a model of fear memory formation in which intrinsic excitability determines neuronal selection, whereas learning-related encoding is governed by synaptic plasticity. Twit Text FOAVip Arc expression identifies the lateral amygdala fear memory trace ????Mol Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=25802982 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25802982 #FOAvip English Wikipedia <ref>{{Cite pmid|25802982}}</ref> Arc expression identifies the lateral amygdala fear memory trace #MMPMID25802982 Gouty-Colomer LA; Hosseini B; Marcelo IM; Schreiber J; Slump DE; Yamaguchi S; Houweling AR; Jaarsma D; Elgersma Y; Kushner SA Mol Psychiatry 2016[Mar]; 21 (3): 364-75 PMID25802982show ga Memories are encoded within sparsely distributed neuronal ensembles. However, the defining cellular properties of neurons within a memory trace remain incompletely understood. Using a fluorescence-based Arc reporter, we were able to visually identify the distinct subset of lateral amygdala (LA) neurons activated during auditory fear conditioning. We found that Arc-expressing neurons have enhanced intrinsic excitability and are preferentially recruited into newly encoded memory traces. Furthermore, synaptic potentiation of thalamic inputs to the LA during fear conditioning is learning-specific, postsynaptically mediated and highly localized to Arc-expressing neurons. Taken together, our findings validate the immediate-early gene Arc as a molecular marker for the LA neuronal ensemble recruited during fear learning. Moreover, these results establish a model of fear memory formation in which intrinsic excitability determines neuronal selection, whereas learning-related encoding is governed by synaptic plasticity. äArc expression identifies the lateral amygdala fear memory trace (epmc).pdf DeepDyve Pubget Overpricing