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10.3978/j.issn.2218-6751.2016.01.13

http://scihub22266oqcxt.onion/10.3978/j.issn.2218-6751.2016.01.13
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C4758961!4758961!26958491
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suck abstract from ncbi


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pmid26958491      Transl+Lung+Cancer+Res 2016 ; 5 (1): 26-38
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  • Treatment for small cell lung cancer, where are we now??a review #MMPMID26958491
  • Alvarado-Luna G; Morales-Espinosa D
  • Transl Lung Cancer Res 2016[Feb]; 5 (1): 26-38 PMID26958491show ga
  • Small cell lung cancer (SCLC) represents between 13% and 15% of all diagnosed lung cancers worldwide. It is an aggressive neoplasia, with a 5-year mortality of 90% or more. It has historically been classified as limited disease (LD) and extensive disease (ED) in most study protocols. The cornerstone of treatment for any stage of SCLC is etoposide-platinum based chemotherapy; in limited stage (LS), concomitant radiotherapy to thorax and mediastinum. Prophylactic radiotherapy to the central nervous system (CNS) [prophylactic cerebral irradiation (PCI)] has diminished the incidence of brain metastasis as the site for relapse in LD and ED patients, therefore it should be offered to patients with complete response to induction first-line treatment. Regarding second-line treatment, results are more modest and topotecan is accepted as treatment for this scenario offering a modest benefit.
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