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10.1111/imr.12390 http://scihub22266oqcxt.onion/10.1111/imr.12390 C4758696!4758696!26864110     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunol+Rev 2016 ; 270 (1): 152-64 Nephropedia Template TP {{tp|p=26864110|t=2016. Immunogenicity of therapeutic recombinant immunotoxins |pdf=|usr=}}{{26864110}} gab.com Text Immunogenicity of therapeutic recombinant immunotoxins JO: Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=26864110 #FOAvip Recombinant Immunotoxins (RITs) are chimeric proteins designed to treat cancer. They are made up of an Fv or Fab that targets an antigen on a cancer cell fused to a 38 kDa portion of Pseudomonas exotoxin A (PE38). Because PE38 is a bacterial protein, it is highly immunogenic in patients with solid tumors that have normal immune systems, but much less immunogenic in patients with hematologic malignancies where the immune system is suppressed. RITs have shown efficacy in refractory hairy cell leukemia and in some children with acute lymphoblastic leukemia, but have been much less effective in solid tumors, because neutralizing antibodies develop and prevent additional treatment cycles. In this paper we will 1) review data from clinical trials describing the immunogenicity of PE38 in different patient populations, 2) review results form clinical trials using different immunosuppressive drugs and 3) describe our efforts to make new less-immunogenic RITs by identifying and removing T and B cell epitopes to hide the RIT from the immune system. Twit Text FOAVip Immunogenicity of therapeutic recombinant immunotoxins ????Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=26864110 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26864110 #FOAvip English Wikipedia <ref>{{Cite pmid|26864110}}</ref> Immunogenicity of therapeutic recombinant immunotoxins #MMPMID26864110 Mazor R; Onda M; Pastan I Immunol Rev 2016[Mar]; 270 (1): 152-64 PMID26864110show ga Recombinant Immunotoxins (RITs) are chimeric proteins designed to treat cancer. They are made up of an Fv or Fab that targets an antigen on a cancer cell fused to a 38 kDa portion of Pseudomonas exotoxin A (PE38). Because PE38 is a bacterial protein, it is highly immunogenic in patients with solid tumors that have normal immune systems, but much less immunogenic in patients with hematologic malignancies where the immune system is suppressed. RITs have shown efficacy in refractory hairy cell leukemia and in some children with acute lymphoblastic leukemia, but have been much less effective in solid tumors, because neutralizing antibodies develop and prevent additional treatment cycles. In this paper we will 1) review data from clinical trials describing the immunogenicity of PE38 in different patient populations, 2) review results form clinical trials using different immunosuppressive drugs and 3) describe our efforts to make new less-immunogenic RITs by identifying and removing T and B cell epitopes to hide the RIT from the immune system. äImmunogenicity of therapeutic recombinant immunotoxins (epmc).pdf DeepDyve Pubget Overpricing