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10.1016/j.kint.2015.11.017 http://scihub22266oqcxt.onion/10.1016/j.kint.2015.11.017 C4757817!4757817 !26880456     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26880456 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Kidney+Int 2016 ; 89 (3 ): 612-24 Nephropedia Template TP {{tp|p=26880456 |t=2016. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis |pdf=|usr=}}{{26880456 }} gab.com Text Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis JO: Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=26880456 #FOAvip Proper development and maintenance of urothelium is critical to its function. Uroplakins are expressed in developing and mature urothelium where they establish plaques associated with the permeability barrier. Their precise functional role in development and disease is unknown. Here, we disrupted Upk1b in vivo where its loss resulted in urothelial plaque disruption in the bladder and kidney. Upk1b(RFP/RFP) bladder urothelium appeared dysplastic with expansion of the progenitor cell markers, Krt14 and Krt5, increased Shh expression, and loss of terminal differentiation markers Krt20 and uroplakins. Upk1b(RFP/RFP) renal urothelium became stratified with altered cellular composition. Upk1b(RFP/RFP) mice developed age-dependent progressive hydronephrosis. Interestingly, 16% of Upk1b(RFP/RFP) mice possessed unilateral duplex kidneys. Our study expands the role of uroplakins, mechanistically links plaque formation to urinary tract development and function, and provides a tantalizing connection between congenital anomalies of the kidney and urinary tract along with functional deficits observed in a variety of urinary tract diseases. Thus, kidney and bladder urothelium are regionally distinct and remain highly plastic, capable of expansion through tissue-specific progenitor populations. Furthermore, Upk1b plays a previously unknown role in early kidney development representing a novel genetic target for congenital anomalies of the kidney and urinary tract. Twit Text FOAVip Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis ????Kidney Int http://www.kidney.de/pget.php?&tw=1&pmid=26880456 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26880456 #FOAvip English Wikipedia <ref>{{Cite pmid|26880456 }}</ref> Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis #MMPMID26880456 Carpenter AR ; Becknell MB ; Ching CB ; Cuaresma EJ ; Chen X ; Hains DS ; McHugh KM Kidney Int 2016[Mar]; 89 (3 ): 612-24 PMID26880456 show ga Proper development and maintenance of urothelium is critical to its function. Uroplakins are expressed in developing and mature urothelium where they establish plaques associated with the permeability barrier. Their precise functional role in development and disease is unknown. Here, we disrupted Upk1b in vivo where its loss resulted in urothelial plaque disruption in the bladder and kidney. Upk1b(RFP/RFP) bladder urothelium appeared dysplastic with expansion of the progenitor cell markers, Krt14 and Krt5, increased Shh expression, and loss of terminal differentiation markers Krt20 and uroplakins. Upk1b(RFP/RFP) renal urothelium became stratified with altered cellular composition. Upk1b(RFP/RFP) mice developed age-dependent progressive hydronephrosis. Interestingly, 16% of Upk1b(RFP/RFP) mice possessed unilateral duplex kidneys. Our study expands the role of uroplakins, mechanistically links plaque formation to urinary tract development and function, and provides a tantalizing connection between congenital anomalies of the kidney and urinary tract along with functional deficits observed in a variety of urinary tract diseases. Thus, kidney and bladder urothelium are regionally distinct and remain highly plastic, capable of expansion through tissue-specific progenitor populations. Furthermore, Upk1b plays a previously unknown role in early kidney development representing a novel genetic target for congenital anomalies of the kidney and urinary tract. |*Cell Differentiation [MESH] |Animals [MESH] |Cell Proliferation [MESH] |Gene Expression Regulation, Developmental [MESH] |Genotype [MESH] |Homeostasis [MESH] |Hydronephrosis/genetics/metabolism [MESH] |Kidney/abnormalities/*metabolism/ultrastructure [MESH] |Mice, Knockout [MESH] |Phenotype [MESH] |Signal Transduction [MESH] |Tetraspanins/deficiency/genetics/*metabolism [MESH] |Urinary Bladder/abnormalities/*metabolism/ultrastructure [MESH] |Urogenital Abnormalities/genetics/metabolism [MESH] |Uroplakin Ib [MESH] |Urothelium/abnormalities/*metabolism/ultrastructure [MESH]Uroplakin 1b is critical in urinary tract development and urothelial (epmc).pdf DeepDyve Pubget Overpricing