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10.1038/ncomms10684 http://scihub22266oqcxt.onion/10.1038/ncomms10684 C4757793!4757793!26883450     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26883450|t=2016. Intraoperative intravital microscopy permits the study of human tumour vessels |pdf=|usr=}}{{26883450}} gab.com Text Intraoperative intravital microscopy permits the study of human tumour vessels JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26883450 #FOAvip Tumour vessels have been studied extensively as they are critical sites for drug delivery, anti-angiogenic therapies and immunotherapy. As a preclinical tool, intravital microscopy (IVM) allows for in vivo real-time direct observation of vessels at the cellular level. However, to date there are no reports of intravital high-resolution imaging of human tumours in the clinical setting. Here we report the feasibility of IVM examinations of human malignant disease with an emphasis on tumour vasculature as the major site of tumour-host interactions. Consistent with preclinical observations, we show that patient tumour vessels are disorganized, tortuous and ?50% do not support blood flow. Human tumour vessel diameters are larger than predicted from immunohistochemistry or preclinical IVM, and thereby have lower wall shear stress, which influences delivery of drugs and cellular immunotherapies. Thus, real-time clinical imaging of living human tumours is feasible and allows for detection of characteristics within the tumour microenvironment. Twit Text FOAVip Intraoperative intravital microscopy permits the study of human tumour vessels ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26883450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26883450 #FOAvip English Wikipedia <ref>{{Cite pmid|26883450}}</ref> Intraoperative intravital microscopy permits the study of human tumour vessels #MMPMID26883450 Fisher DT; Muhitch JB; Kim M; Doyen KC; Bogner PN; Evans SS; Skitzki JJ Nat Commun 2016[]; 7 (ä): ä PMID26883450show ga Tumour vessels have been studied extensively as they are critical sites for drug delivery, anti-angiogenic therapies and immunotherapy. As a preclinical tool, intravital microscopy (IVM) allows for in vivo real-time direct observation of vessels at the cellular level. However, to date there are no reports of intravital high-resolution imaging of human tumours in the clinical setting. Here we report the feasibility of IVM examinations of human malignant disease with an emphasis on tumour vasculature as the major site of tumour-host interactions. Consistent with preclinical observations, we show that patient tumour vessels are disorganized, tortuous and ?50% do not support blood flow. Human tumour vessel diameters are larger than predicted from immunohistochemistry or preclinical IVM, and thereby have lower wall shear stress, which influences delivery of drugs and cellular immunotherapies. Thus, real-time clinical imaging of living human tumours is feasible and allows for detection of characteristics within the tumour microenvironment. äIntraoperative intravital microscopy permits the study of human tumour(epmc).pdf DeepDyve Pubget Overpricing