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10.1038/ncomms10686 http://scihub22266oqcxt.onion/10.1038/ncomms10686 C4757769!4757769!26880110     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26880110&cmd=llinks): Failed to open stream: HTTP request failed! 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Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion |pdf=|usr=}}{{26880110}} gab.com Text Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26880110 #FOAvip Proper regulation of energy storage in adipose tissue is crucial for maintaining insulin sensitivity and molecules contributing to this process have not been fully revealed. Here we show that type II transmembrane protein tenomodulin (TNMD) is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive individuals, who were matched for body mass index (BMI). TNMD expression increases in human preadipocytes during differentiation, whereas silencing TNMD blocks adipogenesis. Upon high-fat diet feeding, transgenic mice overexpressing Tnmd develop increased epididymal white adipose tissue (eWAT) mass, and preadipocytes derived from Tnmd transgenic mice display greater proliferation, consistent with elevated adipogenesis. In Tnmd transgenic mice, lipogenic genes are upregulated in eWAT, as is Ucp1 in brown fat, while liver triglyceride accumulation is attenuated. Despite expanded eWAT, transgenic animals display improved systemic insulin sensitivity, decreased collagen deposition and inflammation in eWAT, and increased insulin stimulation of Akt phosphorylation. Our data suggest that TNMD acts as a protective factor in visceral adipose tissue to alleviate insulin resistance in obesity. Twit Text FOAVip Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26880110 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26880110 #FOAvip English Wikipedia <ref>{{Cite pmid|26880110}}</ref> Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion #MMPMID26880110 Senol-Cosar O; Flach RJR; DiStefano M; Chawla A; Nicoloro S; Straubhaar J; Hardy OT; Noh HL; Kim JK; Wabitsch M; Scherer PE; Czech MP Nat Commun 2016[]; 7 (ä): ä PMID26880110show ga Proper regulation of energy storage in adipose tissue is crucial for maintaining insulin sensitivity and molecules contributing to this process have not been fully revealed. Here we show that type II transmembrane protein tenomodulin (TNMD) is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive individuals, who were matched for body mass index (BMI). TNMD expression increases in human preadipocytes during differentiation, whereas silencing TNMD blocks adipogenesis. Upon high-fat diet feeding, transgenic mice overexpressing Tnmd develop increased epididymal white adipose tissue (eWAT) mass, and preadipocytes derived from Tnmd transgenic mice display greater proliferation, consistent with elevated adipogenesis. In Tnmd transgenic mice, lipogenic genes are upregulated in eWAT, as is Ucp1 in brown fat, while liver triglyceride accumulation is attenuated. Despite expanded eWAT, transgenic animals display improved systemic insulin sensitivity, decreased collagen deposition and inflammation in eWAT, and increased insulin stimulation of Akt phosphorylation. Our data suggest that TNMD acts as a protective factor in visceral adipose tissue to alleviate insulin resistance in obesity. äTenomodulin promotes human adipocyte differentiation and beneficial vi(epmc).pdf DeepDyve Pubget Overpricing