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10.1038/ni.3348 http://scihub22266oqcxt.onion/10.1038/ni.3348 C4757736!4757736 !26779600     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26779600 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Immunol 2016 ; 17 (3 ): 323-30 Nephropedia Template TP {{tp|p=26779600 |t=2016. Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response |pdf=|usr=}}{{26779600 }} gab.com Text Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26779600 #FOAvip Plasma cell differentiation requires silencing of B cell transcription, while it establishes antibody-secretory function and long-term survival. The transcription factors Blimp-1 and IRF4 are essential for the generation of plasma cells; however, their function in mature plasma cells has remained elusive. We found that while IRF4 was essential for the survival of plasma cells, Blimp-1 was dispensable for this. Blimp-1-deficient plasma cells retained their transcriptional identity but lost the ability to secrete antibody. Blimp-1 regulated many components of the unfolded protein response (UPR), including XBP-1 and ATF6. The overlap in the functions of Blimp-1 and XBP-1 was restricted to that response, with Blimp-1 uniquely regulating activity of the kinase mTOR and the size of plasma cells. Thus, Blimp-1 was required for the unique physiological ability of plasma cells that enables the secretion of protective antibody. Twit Text FOAVip Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26779600 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26779600 #FOAvip English Wikipedia <ref>{{Cite pmid|26779600 }}</ref> Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response #MMPMID26779600 Tellier J ; Shi W ; Minnich M ; Liao Y ; Crawford S ; Smyth GK ; Kallies A ; Busslinger M ; Nutt SL Nat Immunol 2016[Mar]; 17 (3 ): 323-30 PMID26779600 show ga Plasma cell differentiation requires silencing of B cell transcription, while it establishes antibody-secretory function and long-term survival. The transcription factors Blimp-1 and IRF4 are essential for the generation of plasma cells; however, their function in mature plasma cells has remained elusive. We found that while IRF4 was essential for the survival of plasma cells, Blimp-1 was dispensable for this. Blimp-1-deficient plasma cells retained their transcriptional identity but lost the ability to secrete antibody. Blimp-1 regulated many components of the unfolded protein response (UPR), including XBP-1 and ATF6. The overlap in the functions of Blimp-1 and XBP-1 was restricted to that response, with Blimp-1 uniquely regulating activity of the kinase mTOR and the size of plasma cells. Thus, Blimp-1 was required for the unique physiological ability of plasma cells that enables the secretion of protective antibody. |Activating Transcription Factor 6/genetics/immunology [MESH] |Animals [MESH] |Cell Differentiation/*immunology [MESH] |Cell Size [MESH] |Chromatin Immunoprecipitation [MESH] |DNA-Binding Proteins/genetics/immunology [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Flow Cytometry [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Immunoglobulins/*immunology/metabolism [MESH] |Interferon Regulatory Factors/genetics/*immunology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Microscopy, Electron, Transmission [MESH] |Plasma Cells/*immunology/metabolism [MESH] |Positive Regulatory Domain I-Binding Factor 1 [MESH] |Regulatory Factor X Transcription Factors [MESH] |Sequence Analysis, DNA [MESH] |TOR Serine-Threonine Kinases/genetics/immunology [MESH] |Transcription Factors/genetics/*immunology [MESH] |Unfolded Protein Response/genetics/*immunology [MESH]Blimp-1 controls plasma cell function through the regulation of immuno(epmc).pdf DeepDyve Pubget Overpricing