Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26949507
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
The discovery of a novel antibiotic for the treatment of Clostridium difficile
infections: a story of an effective academic-industrial partnership
#MMPMID26949507
Mann J
; Taylor PW
; Dorgan CR
; Johnson PD
; Wilson FX
; Vickers R
; Dale AG
; Neidle S
Medchemcomm
2015[Aug]; 6
(8
): 1420-1426
PMID26949507
show ga
Academic drug discovery is playing an increasingly important role in the
identification of new therapies for a wide range of diseases. There is no one
model that guarantees success. We describe here a drug discovery story where
chance, the ability to capitalise on chance, and the assembling of a range of
expertise, have all played important roles in the discovery and subsequent
development of an antibiotic chemotype based on the bis-benzimidazole scaffold,
with potency against a number of current therapeutically challenging diseases.
One compound in this class, SMT19969, has recently entered Phase 2 human clinical
trials for the treatment of Clostridium difficile infections.