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10.1039/c5md00238a

http://scihub22266oqcxt.onion/10.1039/c5md00238a
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suck abstract from ncbi

pmid26949507
      Medchemcomm 2015 ; 6 (8 ): 1420-1426
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  • The discovery of a novel antibiotic for the treatment of Clostridium difficile infections: a story of an effective academic-industrial partnership #MMPMID26949507
  • Mann J ; Taylor PW ; Dorgan CR ; Johnson PD ; Wilson FX ; Vickers R ; Dale AG ; Neidle S
  • Medchemcomm 2015[Aug]; 6 (8 ): 1420-1426 PMID26949507 show ga
  • Academic drug discovery is playing an increasingly important role in the identification of new therapies for a wide range of diseases. There is no one model that guarantees success. We describe here a drug discovery story where chance, the ability to capitalise on chance, and the assembling of a range of expertise, have all played important roles in the discovery and subsequent development of an antibiotic chemotype based on the bis-benzimidazole scaffold, with potency against a number of current therapeutically challenging diseases. One compound in this class, SMT19969, has recently entered Phase 2 human clinical trials for the treatment of Clostridium difficile infections.
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