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10.1016/j.bbmt.2015.12.005

http://scihub22266oqcxt.onion/10.1016/j.bbmt.2015.12.005
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C4756459!4756459!26712591
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suck abstract from ncbi

pmid26712591      Biol+Blood+Marrow+Transplant 2016 ; 22 (3): 557-63
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  • Observational Studies: Matching or Regression? #MMPMID26712591
  • Brazauskas R; Logan BR
  • Biol Blood Marrow Transplant 2016[Mar]; 22 (3): 557-63 PMID26712591show ga
  • In observational studies with an aim of assessing treatment effect or comparing groups of patients, several approaches could be employed. Often baseline characteristics of the patients may be imbalanced between the groups and adjustments are needed to account for this. It can be accomplished either via appropriate regression modeling or, alternatively, by conducting a matched pairs study. The latter is often chosen because it makes the groups appear comparable. In this article, we considered these two options in terms of their ability to detect a treatment effect in time-to-event studies. Our investigation shows that Cox regression model applied to the entire cohort is often a more powerful tool in detecting treatment effect as compared to a matched study. Real data from a hematopoietic cell transplantation study is used as an example.
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