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10.1038/ncomms10570 http://scihub22266oqcxt.onion/10.1038/ncomms10570 C4756352!4756352!26875526     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26875526|t=2016. Atypical natural killer T-cell receptor recognition of CD1d?lipid antigens |pdf=|usr=}}{{26875526}} gab.com Text Atypical natural killer T-cell receptor recognition of CD1d lipid antigens JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26875526 #FOAvip Crucial to Natural Killer T (NKT) cell function is the interaction between their T-cell receptor (TCR) and CD1d-antigen complex. However, the diversity of the NKT cell repertoire and the ensuing interactions with CD1d-antigen remain unclear. We describe an atypical population of CD1d??-galactosylceramide (?-GalCer)-reactive human NKT cells that differ markedly from the prototypical TRAV10-TRAJ18-TRBV25-1+ type I NKT cell repertoire. These cells express a range of TCR ?- and ?-chains that show differential recognition of glycolipid antigens. Two atypical NKT TCRs (TRAV21-TRAJ8-TRBV7?8 and TRAV12-3-TRAJ27-TRBV6-5) bind orthogonally over the A?-pocket of CD1d, adopting distinct docking modes that contrast with the docking mode of all type I NKT TCR-CD1d-antigen complexes. Moreover, the interactions with ?-GalCer differ between the type I and these atypical NKT TCRs. Accordingly, diverse NKT TCR repertoire usage manifests in varied docking strategies and specificities towards CD1d??-GalCer and related antigens, thus providing far greater scope for diverse glycolipid antigen recognition. Twit Text FOAVip Atypical natural killer T-cell receptor recognition of CD1d lipid antigens ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26875526 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26875526 #FOAvip English Wikipedia <ref>{{Cite pmid|26875526}}</ref> Atypical natural killer T-cell receptor recognition of CD1d?lipid antigens #MMPMID26875526 Le Nours J; Praveena T; Pellicci DG; Gherardin NA; Ross FJ; Lim RT; Besra GS; Keshipeddy S; Richardson SK; Howell AR; Gras S; Godfrey DI; Rossjohn J; Uldrich AP Nat Commun 2016[]; 7 (ä): ä PMID26875526show ga Crucial to Natural Killer T (NKT) cell function is the interaction between their T-cell receptor (TCR) and CD1d-antigen complex. However, the diversity of the NKT cell repertoire and the ensuing interactions with CD1d-antigen remain unclear. We describe an atypical population of CD1d??-galactosylceramide (?-GalCer)-reactive human NKT cells that differ markedly from the prototypical TRAV10-TRAJ18-TRBV25-1+ type I NKT cell repertoire. These cells express a range of TCR ?- and ?-chains that show differential recognition of glycolipid antigens. Two atypical NKT TCRs (TRAV21-TRAJ8-TRBV7?8 and TRAV12-3-TRAJ27-TRBV6-5) bind orthogonally over the A?-pocket of CD1d, adopting distinct docking modes that contrast with the docking mode of all type I NKT TCR-CD1d-antigen complexes. Moreover, the interactions with ?-GalCer differ between the type I and these atypical NKT TCRs. Accordingly, diverse NKT TCR repertoire usage manifests in varied docking strategies and specificities towards CD1d??-GalCer and related antigens, thus providing far greater scope for diverse glycolipid antigen recognition. äAtypical natural killer T-cell receptor recognition of CD1d?lipid anti(epmc).pdf DeepDyve Pubget Overpricing