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10.1155/2016/4693801 http://scihub22266oqcxt.onion/10.1155/2016/4693801 C4756195!4756195!26955430     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oxid+Med+Cell+Longev 2016 ; 2016 (ä): ä Nephropedia Template TP {{tp|p=26955430|t=2016. Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes |pdf=|usr=}}{{26955430}} gab.com Text Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes JO: Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=26955430 #FOAvip This study addressed the relationship of proinflammatory cytokines and Nrf2-Keap1 system in diabetic nephropathy. The experimental groups were control, diabetic, and diabetic treated with mycophenolate mofetil (MMF). The renal function, proinflammatory and profibrotic cytokines, oxidative stress, morphology, and nephrin expression were assessed. Diabetic group showed impaired renal function in association with oxidative stress and decreased Nrf2 nuclear translocation. These results were associated with increased mesangial matrix index, interstitial fibrosis, and increased nephrin expression in cortex and urine excretion. Additionally, interleukin-1?, IL-6, and transforming growth factor-?1 were increased in plasma and kidney. MMF treatment conserved renal function, prevented renal structural alterations, and partially prevented the proinflammatory and profibrotic cytokines overexpression. Despite that MMF treatment induced nephrin overexpression in renal tissue, preventing its urinary loss. MMF salutary effects were associated with a partial prevention of oxidative stress, increased Nrf2 nuclear translocation, and conservation of antioxidant enzymes in renal tissue. In conclusion, our results confirm that inflammation is a key factor in the progression of diabetic nephropathy and suggest that treatment with MMF protects the kidney by an antioxidant mechanism, possibly regulated at least in part by the Nrf2/Keap1 system, in addition to its well-known anti-inflammatory effects. Twit Text FOAVip Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes ????Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=26955430 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26955430 #FOAvip English Wikipedia <ref>{{Cite pmid|26955430}}</ref> Anti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats with Diabetes #MMPMID26955430 Arellano-Buendía AS; Tostado-González M; García-Arroyo FE; Cristóbal-García M; Loredo-Mendoza ML; Tapia E; Sánchez-Lozada LG; Osorio-Alonso H Oxid Med Cell Longev 2016[]; 2016 (ä): ä PMID26955430show ga This study addressed the relationship of proinflammatory cytokines and Nrf2-Keap1 system in diabetic nephropathy. The experimental groups were control, diabetic, and diabetic treated with mycophenolate mofetil (MMF). The renal function, proinflammatory and profibrotic cytokines, oxidative stress, morphology, and nephrin expression were assessed. Diabetic group showed impaired renal function in association with oxidative stress and decreased Nrf2 nuclear translocation. These results were associated with increased mesangial matrix index, interstitial fibrosis, and increased nephrin expression in cortex and urine excretion. Additionally, interleukin-1?, IL-6, and transforming growth factor-?1 were increased in plasma and kidney. MMF treatment conserved renal function, prevented renal structural alterations, and partially prevented the proinflammatory and profibrotic cytokines overexpression. Despite that MMF treatment induced nephrin overexpression in renal tissue, preventing its urinary loss. MMF salutary effects were associated with a partial prevention of oxidative stress, increased Nrf2 nuclear translocation, and conservation of antioxidant enzymes in renal tissue. In conclusion, our results confirm that inflammation is a key factor in the progression of diabetic nephropathy and suggest that treatment with MMF protects the kidney by an antioxidant mechanism, possibly regulated at least in part by the Nrf2/Keap1 system, in addition to its well-known anti-inflammatory effects. äAnti-Inflammatory Therapy Modulates Nrf2-Keap1 in Kidney from Rats wit(epmc).pdf DeepDyve Pubget Overpricing