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10.1016/j.cell.2015.12.033 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.12.033 C4752822!4752822!26871632     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 164 (4): 668-80 Nephropedia Template TP {{tp|p=26871632|t=2016. Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause |pdf=|usr=}}{{26871632}} gab.com Text Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26871632 #FOAvip Mouse embryonic stem cells (ESCs) are maintained in a naive ground state of pluripotency in the presence of MEK and GSK3 inhibitors. Here, we show that ground-state ESCs express low Myc levels. Deletion of both c-myc and N-myc (dKO) or pharmacological inhibition of Myc activity strongly decreases transcription, splicing, and protein synthesis, leading to proliferation arrest. This process is reversible and occurs without affecting pluripotency, suggesting that Myc-depleted stem cells enter a state of dormancy similar to embryonic diapause. Indeed, c-Myc is depleted in diapaused blastocysts, and the differential expression signatures of dKO ESCs and diapaused epiblasts are remarkably similar. Following Myc inhibition, pre-implantation blastocysts enter biosynthetic dormancy but can progress through their normal developmental program after transfer into pseudo-pregnant recipients. Our study shows that Myc controls the biosynthetic machinery of stem cells without affecting their potency, thus regulating their entry and exit from the dormant state. Twit Text FOAVip Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26871632 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26871632 #FOAvip English Wikipedia <ref>{{Cite pmid|26871632}}</ref> Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause #MMPMID26871632 Scognamiglio R; Cabezas-Wallscheid N; Thier M; Altamura S; Reyes A; Prendergast Á; Baumgärtner D; Carnevalli L; Atzberger A; Haas S; von Paleske L; Boroviak T; Wörsdörfer P; Essers M; Kloz U; Eisenman R; Edenhofer F; Bertone P; Huber W; van der Hoeven F; Smith A; Trumpp A Cell 2016[Feb]; 164 (4): 668-80 PMID26871632show ga Mouse embryonic stem cells (ESCs) are maintained in a naive ground state of pluripotency in the presence of MEK and GSK3 inhibitors. Here, we show that ground-state ESCs express low Myc levels. Deletion of both c-myc and N-myc (dKO) or pharmacological inhibition of Myc activity strongly decreases transcription, splicing, and protein synthesis, leading to proliferation arrest. This process is reversible and occurs without affecting pluripotency, suggesting that Myc-depleted stem cells enter a state of dormancy similar to embryonic diapause. Indeed, c-Myc is depleted in diapaused blastocysts, and the differential expression signatures of dKO ESCs and diapaused epiblasts are remarkably similar. Following Myc inhibition, pre-implantation blastocysts enter biosynthetic dormancy but can progress through their normal developmental program after transfer into pseudo-pregnant recipients. Our study shows that Myc controls the biosynthetic machinery of stem cells without affecting their potency, thus regulating their entry and exit from the dormant state. äMyc Depletion Induces a Pluripotent Dormant State Mimicking Diapause (epmc).pdf DeepDyve Pubget Overpricing