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10.1016/j.cell.2016.01.028 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.01.028 C4752819!4752819!26871631     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 164 (4): 656-67 Nephropedia Template TP {{tp|p=26871631|t=2016. Self-Organization of Embryonic Genetic Oscillators into Spatiotemporal Wave Patterns |pdf=|usr=}}{{26871631}} gab.com Text Self-Organization of Embryonic Genetic Oscillators into Spatiotemporal Wave Patterns JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=26871631 #FOAvip In vertebrate embryos, somites, the precursor of vertebrae, form from the presomitic mesoderm (PSM), which is composed of cells displaying signaling oscillations. Cellular oscillatory activity leads to periodic wave patterns in the PSM. Here, we address the origin of such complex wave patterns. We employed an in vitro randomization and real-time imaging strategy to probe for the ability of cells to generate order from disorder. We found that, after randomization, PSM cells self-organized into several miniature emergent PSM structures (ePSM). Our results show an ordered macroscopic spatial arrangement of ePSM with evidence of an intrinsic length scale. Furthermore, cells actively synchronize oscillations in a Notch-signaling-dependent manner, re-establishing wave-like patterns of gene activity. We demonstrate that PSM cells self-organize by tuning oscillation dynamics in response to surrounding cells, leading to collective synchronization with an average frequency. These findings reveal emergent properties within an ensemble of coupled genetic oscillators. Twit Text FOAVip Self-Organization of Embryonic Genetic Oscillators into Spatiotemporal Wave Patterns ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=26871631 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26871631 #FOAvip English Wikipedia <ref>{{Cite pmid|26871631}}</ref> Self-Organization of Embryonic Genetic Oscillators into Spatiotemporal Wave Patterns #MMPMID26871631 Tsiairis C; Aulehla A Cell 2016[Feb]; 164 (4): 656-67 PMID26871631show ga In vertebrate embryos, somites, the precursor of vertebrae, form from the presomitic mesoderm (PSM), which is composed of cells displaying signaling oscillations. Cellular oscillatory activity leads to periodic wave patterns in the PSM. Here, we address the origin of such complex wave patterns. We employed an in vitro randomization and real-time imaging strategy to probe for the ability of cells to generate order from disorder. We found that, after randomization, PSM cells self-organized into several miniature emergent PSM structures (ePSM). Our results show an ordered macroscopic spatial arrangement of ePSM with evidence of an intrinsic length scale. Furthermore, cells actively synchronize oscillations in a Notch-signaling-dependent manner, re-establishing wave-like patterns of gene activity. We demonstrate that PSM cells self-organize by tuning oscillation dynamics in response to surrounding cells, leading to collective synchronization with an average frequency. These findings reveal emergent properties within an ensemble of coupled genetic oscillators. äSelf-Organization of Embryonic Genetic Oscillators into Spatiotemporal(epmc).pdf DeepDyve Pubget Overpricing