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10.1161/HYPERTENSIONAHA.115.06194 http://scihub22266oqcxt.onion/10.1161/HYPERTENSIONAHA.115.06194 C4752410!4752410!26781276     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hypertension 2016 ; 67 (3): 661-8 Nephropedia Template TP {{tp|p=26781276|t=2016. A low salt diet and circadian dysfunction synergize to induce angiotensin II-dependent hypertension in mice |pdf=|usr=}}{{26781276}} gab.com Text A low salt diet and circadian dysfunction synergize to induce angiotensin II-dependent hypertension in mice JO: Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=26781276 #FOAvip Blood pressure exhibits a robust circadian rhythm in health. In hypertension, sleep apnea, and even shift work, this balanced rhythm is perturbed via elevations in nighttime blood pressure, inflicting silent damage to the vasculature and body organs. Herein, we examined the influence of circadian dysfunction during experimental hypertension in mice. Using radiotelemetry to measure ambulatory blood pressure and activity, the effects of angiotensin II administration were studied in wild-type (WT) and Period isoform knockout mice (Per2-KO, Per2,3-KO and Per1,2,3-KO/PerTKO mice). On a normal diet, administration of Ang II caused caused non-dipping blood pressure and exacerbated vascular hypertrophy in the Period isoform knockout mice. To study the endogenous effects of Ang II stimulation, we then administered a low salt diet to the mice, which does stimulate endogenous Ang II in addition to lowering blood pressure. A low salt diet decreased blood pressure in WT mice. In contrast, Period isoform knockout mice lost their circadian rhythm in blood pressure on a low salt diet, due to an increase in resting blood pressure, which was restorable to rhythmicity by the angiotensin receptor blocker losartan. Chronic low salt caused vascular hypertrophy in Period isoform knockout mice which also exhibited increased renin levels and altered AT1 receptor expression. These data suggest that circadian clock genes may act to inhibit or control renin/angiotensin signaling. Moreover, circadian disorders such as sleep apnea and shift work may alter the homeostatic responses to sodium restriction to potentially influence nocturnal hypertension. Twit Text FOAVip A low salt diet and circadian dysfunction synergize to induce angiotensin II-dependent hypertension in mice ????Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=26781276 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26781276 #FOAvip English Wikipedia <ref>{{Cite pmid|26781276}}</ref> A low salt diet and circadian dysfunction synergize to induce angiotensin II-dependent hypertension in mice #MMPMID26781276 Pati P; Fulton DJ; Bagi Z; Chen F; Wang Y; Kitchens J; Cassis LA; Stepp DW; Rudic RD Hypertension 2016[Mar]; 67 (3): 661-8 PMID26781276show ga Blood pressure exhibits a robust circadian rhythm in health. In hypertension, sleep apnea, and even shift work, this balanced rhythm is perturbed via elevations in nighttime blood pressure, inflicting silent damage to the vasculature and body organs. Herein, we examined the influence of circadian dysfunction during experimental hypertension in mice. Using radiotelemetry to measure ambulatory blood pressure and activity, the effects of angiotensin II administration were studied in wild-type (WT) and Period isoform knockout mice (Per2-KO, Per2,3-KO and Per1,2,3-KO/PerTKO mice). On a normal diet, administration of Ang II caused caused non-dipping blood pressure and exacerbated vascular hypertrophy in the Period isoform knockout mice. To study the endogenous effects of Ang II stimulation, we then administered a low salt diet to the mice, which does stimulate endogenous Ang II in addition to lowering blood pressure. A low salt diet decreased blood pressure in WT mice. In contrast, Period isoform knockout mice lost their circadian rhythm in blood pressure on a low salt diet, due to an increase in resting blood pressure, which was restorable to rhythmicity by the angiotensin receptor blocker losartan. Chronic low salt caused vascular hypertrophy in Period isoform knockout mice which also exhibited increased renin levels and altered AT1 receptor expression. These data suggest that circadian clock genes may act to inhibit or control renin/angiotensin signaling. Moreover, circadian disorders such as sleep apnea and shift work may alter the homeostatic responses to sodium restriction to potentially influence nocturnal hypertension. äA low salt diet and circadian dysfunction synergize to induce angioten(epmc).pdf DeepDyve Pubget Overpricing