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10.1091/mbc.E15-09-0632 http://scihub22266oqcxt.onion/10.1091/mbc.E15-09-0632 C4751598!4751598 !26658612     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26658612 &cmd=llinks): Failed to open stream: HTTP request failed! 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APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane |pdf=|usr=}}{{26658612 }} gab.com Text APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane JO: Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26658612 #FOAvip Mutations in adenomatous polyposis coli (APC) disrupt regulation of Wnt signaling, mitosis, and the cytoskeleton. We describe a new role for APC in the transport of mitochondria. Silencing of wild-type APC by small interfering RNA caused mitochondria to redistribute from the cell periphery to the perinuclear region. We identified novel APC interactions with the mitochondrial kinesin-motor complex Miro/Milton that were mediated by the APC C-terminus. Truncating mutations in APC abolished its ability to bind Miro/Milton and reduced formation of the Miro/Milton complex, correlating with disrupted mitochondrial distribution in colorectal cancer cells that could be recovered by reconstitution of wild-type APC. Using proximity ligation assays, we identified endogenous APC-Miro/Milton complexes at mitochondria, and live-cell imaging showed that loss of APC slowed the frequency of anterograde mitochondrial transport to the membrane. We propose that APC helps drive mitochondria to the membrane to supply energy for cellular processes such as directed cell migration, a process disrupted by cancer mutations. Twit Text FOAVip APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane ????Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26658612 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26658612 #FOAvip English Wikipedia <ref>{{Cite pmid|26658612 }}</ref> APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane #MMPMID26658612 Mills KM ; Brocardo MG ; Henderson BR Mol Biol Cell 2016[Feb]; 27 (3 ): 466-82 PMID26658612 show ga Mutations in adenomatous polyposis coli (APC) disrupt regulation of Wnt signaling, mitosis, and the cytoskeleton. We describe a new role for APC in the transport of mitochondria. Silencing of wild-type APC by small interfering RNA caused mitochondria to redistribute from the cell periphery to the perinuclear region. We identified novel APC interactions with the mitochondrial kinesin-motor complex Miro/Milton that were mediated by the APC C-terminus. Truncating mutations in APC abolished its ability to bind Miro/Milton and reduced formation of the Miro/Milton complex, correlating with disrupted mitochondrial distribution in colorectal cancer cells that could be recovered by reconstitution of wild-type APC. Using proximity ligation assays, we identified endogenous APC-Miro/Milton complexes at mitochondria, and live-cell imaging showed that loss of APC slowed the frequency of anterograde mitochondrial transport to the membrane. We propose that APC helps drive mitochondria to the membrane to supply energy for cellular processes such as directed cell migration, a process disrupted by cancer mutations. |Adenomatous Polyposis Coli Protein/chemistry/*physiology [MESH] |Animals [MESH] |Biological Transport [MESH] |Carrier Proteins/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Membrane/physiology/*ultrastructure [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins [MESH] |Mice [MESH] |Microtubules/physiology [MESH] |Mitochondria/*physiology [MESH] |Mitochondrial Proteins/*metabolism [MESH] |Mutation [MESH] |NIH 3T3 Cells [MESH] |Neoplasms/genetics [MESH] |Nerve Tissue Proteins/*metabolism [MESH] |Protein Binding [MESH] |Protein Interaction Domains and Motifs [MESH] |Protein Stability [MESH]APC binds the Miro/Milton motor complex to stimulate transport of mito(epmc).pdf DeepDyve Pubget Overpricing