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10.1016/j.celrep.2016.01.003 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.01.003 C4751304!4751304!26832402     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 14 (5): 1041-8 Nephropedia Template TP {{tp|p=26832402|t=2016. CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3+ T Cells |pdf=|usr=}}{{26832402}} gab.com Text CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3+ T Cells JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26832402 #FOAvip Current models of Foxp3+ regulatory T cell (Treg) development involve CCR7-mediated migration of thymocytes into the thymus medulla to enable essential interactions with medullary epithelium. However, increased Foxp3+ thymic Treg numbers in Ccr7?/? mice challenge this view, and the role of CCR7 in Treg development, emigration, and/or recirculation is unknown. Here, we have examined CCR7 and Rag2pGFP levels during Treg development and generated Rag2pGFPCcr7?/? mice to study its impact on the intrathymic Treg pool. We reveal surprising developmental heterogeneity in thymocytes described as Treg precursors, showing that they contain recirculating CCR6+CCR7?Rag2pGFP? T cells. Although CCR7 defines bona fide Rag2GFP+ Treg precursors, it is not required for Treg production and emigration. Rather, we show that lack of CCR7 renders the thymus more receptive to Treg thymus homing. Our study reveals a role for CCR7 in limiting Treg recirculation back to the thymus and enables separation of the mechanisms controlling Treg production and thymic recirculation. Twit Text FOAVip CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3+ T Cells ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26832402 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26832402 #FOAvip English Wikipedia <ref>{{Cite pmid|26832402}}</ref> CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3+ T Cells #MMPMID26832402 Cowan J; McCarthy N; Anderson G Cell Rep 2016[Feb]; 14 (5): 1041-8 PMID26832402show ga Current models of Foxp3+ regulatory T cell (Treg) development involve CCR7-mediated migration of thymocytes into the thymus medulla to enable essential interactions with medullary epithelium. However, increased Foxp3+ thymic Treg numbers in Ccr7?/? mice challenge this view, and the role of CCR7 in Treg development, emigration, and/or recirculation is unknown. Here, we have examined CCR7 and Rag2pGFP levels during Treg development and generated Rag2pGFPCcr7?/? mice to study its impact on the intrathymic Treg pool. We reveal surprising developmental heterogeneity in thymocytes described as Treg precursors, showing that they contain recirculating CCR6+CCR7?Rag2pGFP? T cells. Although CCR7 defines bona fide Rag2GFP+ Treg precursors, it is not required for Treg production and emigration. Rather, we show that lack of CCR7 renders the thymus more receptive to Treg thymus homing. Our study reveals a role for CCR7 in limiting Treg recirculation back to the thymus and enables separation of the mechanisms controlling Treg production and thymic recirculation. äCCR7 Controls Thymus Recirculation, but Not Production and Emigration,(epmc).pdf DeepDyve Pubget Overpricing