Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1091/mbc.E15-05-0316 http://scihub22266oqcxt.onion/10.1091/mbc.E15-05-0316 C4750920!4750920 !26700317     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26700317 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Biol+Cell 2016 ; 27 (4 ): 599-607 Nephropedia Template TP {{tp|p=26700317 |t=2016. Control of genetic stability by a new heterochromatin compaction pathway involving the Tip60 histone acetyltransferase |pdf=|usr=}}{{26700317 }} gab.com Text Control of genetic stability by a new heterochromatin compaction pathway involving the Tip60 histone acetyltransferase JO: Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26700317 #FOAvip Pericentric heterochromatin is a highly compacted structure required for accurate chromosome segregation in mitosis. In mammals, it relies on methylation of histone H3K9 by Suv39H enzymes, which provides a docking site for HP1 proteins, therefore mediating heterochromatin compaction. Here we show that, when this normal compaction pathway is defective, the histone acetyltransferase Tip60 is recruited to pericentric heterochromatin, where it mediates acetylation of histone H4K12. Furthermore, in such a context, depletion of Tip60 leads to derepression of satellite transcription, decompaction of pericentric heterochromatin, and defects in chromosome segregation in mitosis. Finally, we show that depletion of BRD2, a double bromodomain-containing protein that binds H4K12ac, phenocopies the Tip60 depletion with respect to heterochromatin decompaction and defects in chromosome segregation. Taking the results together, we identify a new compaction pathway of mammalian pericentric heterochromatin relying on Tip60 that might be dependent on BRD2 recruitment by H4K12 acetylation. We propose that the underexpression of Tip60 observed in many human tumors can promote genetic instability via defective pericentric heterochromatin. Twit Text FOAVip Control of genetic stability by a new heterochromatin compaction pathway involving the Tip60 histone acetyltransferase ????Mol Biol Cell http://www.kidney.de/pget.php?&tw=1&pmid=26700317 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26700317 #FOAvip English Wikipedia <ref>{{Cite pmid|26700317 }}</ref> Control of genetic stability by a new heterochromatin compaction pathway involving the Tip60 histone acetyltransferase #MMPMID26700317 Grézy A ; Chevillard-Briet M ; Trouche D ; Escaffit F Mol Biol Cell 2016[Feb]; 27 (4 ): 599-607 PMID26700317 show ga Pericentric heterochromatin is a highly compacted structure required for accurate chromosome segregation in mitosis. In mammals, it relies on methylation of histone H3K9 by Suv39H enzymes, which provides a docking site for HP1 proteins, therefore mediating heterochromatin compaction. Here we show that, when this normal compaction pathway is defective, the histone acetyltransferase Tip60 is recruited to pericentric heterochromatin, where it mediates acetylation of histone H4K12. Furthermore, in such a context, depletion of Tip60 leads to derepression of satellite transcription, decompaction of pericentric heterochromatin, and defects in chromosome segregation in mitosis. Finally, we show that depletion of BRD2, a double bromodomain-containing protein that binds H4K12ac, phenocopies the Tip60 depletion with respect to heterochromatin decompaction and defects in chromosome segregation. Taking the results together, we identify a new compaction pathway of mammalian pericentric heterochromatin relying on Tip60 that might be dependent on BRD2 recruitment by H4K12 acetylation. We propose that the underexpression of Tip60 observed in many human tumors can promote genetic instability via defective pericentric heterochromatin. |Acetylation [MESH] |Animals [MESH] |Chromobox Protein Homolog 5 [MESH] |Chromosomal Instability/*genetics [MESH] |Chromosomal Proteins, Non-Histone/genetics/*metabolism [MESH] |Chromosome Segregation/genetics [MESH] |Heterochromatin/*metabolism [MESH] |Histone Acetyltransferases/genetics/*metabolism [MESH] |Histones/*metabolism [MESH] |Lysine Acetyltransferase 5 [MESH] |Methylation [MESH] |Methyltransferases/genetics/*metabolism [MESH] |Mice [MESH] |Mitosis/genetics [MESH] |NIH 3T3 Cells [MESH] |RNA Interference [MESH] |RNA, Small Interfering/genetics [MESH] |Repressor Proteins/genetics/*metabolism [MESH] |Signal Transduction [MESH] |Trans-Activators/genetics/*metabolism [MESH]Control of genetic stability by a new heterochromatin compaction pathw(epmc).pdf DeepDyve Pubget Overpricing