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10.1111/cei.12723 http://scihub22266oqcxt.onion/10.1111/cei.12723 C4750597!4750597!26440060     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Immunol 2016 ; 183 (3): 317-25 Nephropedia Template TP {{tp|p=26440060|t=2016. DC?SIGN expression on podocytes and its role in inflammatory immune response of lupus nephritis |pdf=|usr=}}{{26440060}} gab.com Text DC SIGN expression on podocytes and its role in inflammatory immune response of lupus nephritis JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26440060 #FOAvip Podocytes, the main target of immune complex, participate actively in the development of glomerular injury as immune cells. Dendritic cell?specific intercellular adhesion molecule?3?grabbing non?integrin (DC?SIGN) is an innate immune molecular that has an immune recognition function, and is involved in mediation of cell adhesion and immunoregulation. Here we explored the expression of DC?SIGN on podocytes and its role in immune and inflammatory responses in lupus nephritis (LN). Expression of DC?SIGN and immunoglobulin (Ig)G1 was observed in glomeruli of LN patients. DC?SIGN was co?expressed with nephrin on podocytes. Accompanied by increased proteinuria of LN mice, DC?SIGN and IgG1 expressions were observed in the glomeruli from 20 weeks, and the renal function deteriorated up to 24 weeks. Mice with anti?DC?SIGN antibody showed reduced proteinuria and remission of renal function. After the podocytes were stimulated by serum of LN mice in vitro, the expression of DC?SIGN, major histocompatibility complex (MHC) class II and CD80 was up?regulated, stimulation of T cell proliferation was enhanced and the interferon (IFN)??/interleukin (IL)?4 ratio increased. However, anti?DC?SIGN antibody treatment reversed these events. These results suggested that podocytes in LN can exert DC?like function through their expression of DC?SIGN, which may be involved in immune and inflammatory responses of renal tissues. However, blockage of DC?SIGN can inhibit immune functions of podocytes, which may have preventive and therapeutic effects. Twit Text FOAVip DC SIGN expression on podocytes and its role in inflammatory immune response of lupus nephritis ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26440060 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26440060 #FOAvip English Wikipedia <ref>{{Cite pmid|26440060}}</ref> DC?SIGN expression on podocytes and its role in inflammatory immune response of lupus nephritis #MMPMID26440060 Cai M; Zhou T; Wang X; Shang M; Zhang Y; Luo M; Xu C; Yuan W Clin Exp Immunol 2016[Mar]; 183 (3): 317-25 PMID26440060show ga Podocytes, the main target of immune complex, participate actively in the development of glomerular injury as immune cells. Dendritic cell?specific intercellular adhesion molecule?3?grabbing non?integrin (DC?SIGN) is an innate immune molecular that has an immune recognition function, and is involved in mediation of cell adhesion and immunoregulation. Here we explored the expression of DC?SIGN on podocytes and its role in immune and inflammatory responses in lupus nephritis (LN). Expression of DC?SIGN and immunoglobulin (Ig)G1 was observed in glomeruli of LN patients. DC?SIGN was co?expressed with nephrin on podocytes. Accompanied by increased proteinuria of LN mice, DC?SIGN and IgG1 expressions were observed in the glomeruli from 20 weeks, and the renal function deteriorated up to 24 weeks. Mice with anti?DC?SIGN antibody showed reduced proteinuria and remission of renal function. After the podocytes were stimulated by serum of LN mice in vitro, the expression of DC?SIGN, major histocompatibility complex (MHC) class II and CD80 was up?regulated, stimulation of T cell proliferation was enhanced and the interferon (IFN)??/interleukin (IL)?4 ratio increased. However, anti?DC?SIGN antibody treatment reversed these events. These results suggested that podocytes in LN can exert DC?like function through their expression of DC?SIGN, which may be involved in immune and inflammatory responses of renal tissues. However, blockage of DC?SIGN can inhibit immune functions of podocytes, which may have preventive and therapeutic effects. äDC?SIGN expression on podocytes and its role in inflammatory immune re(epmc).pdf DeepDyve Pubget Overpricing