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2016 ; 18
(1
): 7-12
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A systematic review of contralateral liver lobe hypertrophy after unilobar
selective internal radiation therapy with Y90
#MMPMID26776845
Teo JY
; Allen JC Jr
; Ng DC
; Choo SP
; Tai DW
; Chang JP
; Cheah FK
; Chow PK
; Goh BK
HPB (Oxford)
2016[Jan]; 18
(1
): 7-12
PMID26776845
show ga
BACKGROUND: Curative liver resection is the treatment of choice for both primary
and secondary liver malignancies. However, an inadequate future liver remnant
(FLR) frequently precludes successful surgery. Portal vein embolization is the
gold-standard modality for inducing hypertrophy of the FLR. In recent times,
unilobar Yttrium-90 selective internal radiation therapy (SIRT) has been reported
to induce hypertrophy of the contralateral, untreated liver lobe. The aim of this
study is to review the current literature reporting on contralateral liver
hypertrophy induced by unilobar SIRT. METHODS: A systematic review of the
English-language literature between 2000 and 2014 was performed using the search
terms "Yttrium 90" OR "selective internal radiation therapy" OR
"radioembolization" AND "hypertrophy". RESULTS: Seven studies, reporting on 312
patients, were included. Two hundred and eighty four patients (91.0%) received
treatment to the right lobe. Two hundred and fifteen patients had hepatocellular
carcinoma (HCC), 12 had intrahepatic cholangiocarcinoma, and 85 had liver
metastases from mixed primaries. Y90 SIRT resulted in contralateral liver
hypertrophy which ranged from 26 to 47% at 44 days-9 months. All studies were
retrospective in nature, and heterogeneous, with substantial variations relative
to pathology treated, underlying liver disease, dosage and delivery of Y90,
number of treatment sessions and time to measurement of hypertrophy. CONCLUSION:
Unilobar Y90 SIRT results in significant hypertrophy of the contralateral liver
lobe. The rate of hypertrophy seems to be slower than that achieved by other
methods.
|*Hepatectomy/adverse effects
[MESH]
|Embolization, Therapeutic/*methods
[MESH]
|Humans
[MESH]
|Hypertrophy
[MESH]
|Liver Failure/etiology/prevention & control
[MESH]