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2016 ; 18
(1
): 98-106
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Effects of loco regional treatments before living donor liver transplantation on
overall survival and recurrence-free survival in South Korean patients with
hepatocellular carcinoma
#MMPMID26776857
Na GH
; Kim EY
; Hong TH
; You YK
; Kim DG
HPB (Oxford)
2016[Jan]; 18
(1
): 98-106
PMID26776857
show ga
BACKGROUND: We evaluated the effects of pre-transplant locoregional treatment on
survival in living donor liver transplantation (LDLT), and the most accurate
method for predicting survival after LDLT in patients who received pre-transplant
locoregional treatment. METHODS: From December 2003 to December 2012, 234
patients underwent LDLT for hepatocellular carcinoma (HCC) at our transplant
center. We retrospectively reviewed 86 patients newly diagnosed with HCC and who
received pre-transplant locoregional treatments at our hospital. RESULTS: Of the
33 patients with HCC initially beyond the Milan criteria, 12 experienced
successful down-staging after locoregional treatments, and the 5-year
recurrence-free survival was 81.8%, which was comparable to those in patients
with HCC initially within the Milan criteria. A bad responder according to the
modified Response Evaluation Criteria in Solid Tumors (mRECIST) [HR, 4.874
(1.059-22.442), p = 0.042], and increased AFP levels [HR 4.002 (1.540-10.397), p
= 0.004] during pre-transplant locoregional treatments were independent risk
factors for HCC recurrence after LDLT in multivariate analysis. CONCLUSIONS:
Liver transplantation may be considered after successful down-staging in patients
with HCC initially beyond the Milan criteria. The mRECIST and serum AFP level
changes are better selection criteria for LDLT in patients who have received
locoregional treatments.