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10.1016/j.celrep.2015.12.101 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.12.101 C4749452!4749452 !26832399     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26832399 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2016 ; 14 (5 ): 1181-1194 Nephropedia Template TP {{tp|p=26832399 |t=2016. Nac1 Coordinates a Sub-network of Pluripotency Factors to Regulate Embryonic Stem Cell Differentiation |pdf=|usr=}}{{26832399 }} gab.com Text Nac1 Coordinates a Sub-network of Pluripotency Factors to Regulate Embryonic Stem Cell Differentiation JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26832399 #FOAvip Pluripotent cells give rise to distinct cell types during development and are regulated by often self-reinforcing molecular networks. How such networks allow cells to differentiate is less well understood. Here, we use integrative methods to show that external signals induce reorganization of the mouse embryonic stem cell pluripotency network and that a sub-network of four factors, Nac1, Oct4, Tcf3, and Sox2, regulates their differentiation into the alternative mesendodermal and neuroectodermal fates. In the mesendodermal fate, Nac1 and Oct4 were constrained within quantitative windows, whereas Sox2 and Tcf3 were repressed. In contrast, in the neuroectodermal fate, Sox2 and Tcf3 were constrained while Nac1 and Oct4 were repressed. In addition, we show that Nac1 coordinates differentiation by activating Oct4 and inhibiting both Sox2 and Tcf3. Reorganization of progenitor cell networks around shared factors might be a common differentiation strategy and our integrative approach provides a general methodology for delineating such networks. Twit Text FOAVip Nac1 Coordinates a Sub-network of Pluripotency Factors to Regulate Embryonic Stem Cell Differentiation ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26832399 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26832399 #FOAvip English Wikipedia <ref>{{Cite pmid|26832399 }}</ref> Nac1 Coordinates a Sub-network of Pluripotency Factors to Regulate Embryonic Stem Cell Differentiation #MMPMID26832399 Malleshaiah M ; Padi M ; Rué P ; Quackenbush J ; Martinez-Arias A ; Gunawardena J Cell Rep 2016[Feb]; 14 (5 ): 1181-1194 PMID26832399 show ga Pluripotent cells give rise to distinct cell types during development and are regulated by often self-reinforcing molecular networks. How such networks allow cells to differentiate is less well understood. Here, we use integrative methods to show that external signals induce reorganization of the mouse embryonic stem cell pluripotency network and that a sub-network of four factors, Nac1, Oct4, Tcf3, and Sox2, regulates their differentiation into the alternative mesendodermal and neuroectodermal fates. In the mesendodermal fate, Nac1 and Oct4 were constrained within quantitative windows, whereas Sox2 and Tcf3 were repressed. In contrast, in the neuroectodermal fate, Sox2 and Tcf3 were constrained while Nac1 and Oct4 were repressed. In addition, we show that Nac1 coordinates differentiation by activating Oct4 and inhibiting both Sox2 and Tcf3. Reorganization of progenitor cell networks around shared factors might be a common differentiation strategy and our integrative approach provides a general methodology for delineating such networks. |*Cell Differentiation/genetics [MESH] |Animals [MESH] |Base Sequence [MESH] |Cell Lineage/genetics [MESH] |Computational Biology [MESH] |Mesoderm/metabolism [MESH] |Mice [MESH] |Molecular Sequence Data [MESH] |Mouse Embryonic Stem Cells/*cytology/*metabolism [MESH] |Nerve Tissue Proteins/*metabolism [MESH] |Neural Plate/metabolism [MESH] |Octamer Transcription Factor-3/metabolism [MESH] |Pluripotent Stem Cells/cytology/*metabolism [MESH] |Protein Binding/genetics [MESH] |Regulatory Sequences, Nucleic Acid/genetics [MESH] |Repressor Proteins/*metabolism [MESH]Nac1 Coordinates a Sub-network of Pluripotency Factors to Regulate Emb(epmc).pdf DeepDyve Pubget Overpricing