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10.1016/j.celrep.2016.01.007 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.01.007 C4749444!4749444!26832405     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 14 (5): 1074-85 Nephropedia Template TP {{tp|p=26832405|t=2016. Fin1-PP1 helps clear spindle assembly checkpoint protein Bub1 from kinetochores in anaphase |pdf=|usr=}}{{26832405}} gab.com Text Fin1-PP1 helps clear spindle assembly checkpoint protein Bub1 from kinetochores in anaphase JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26832405 #FOAvip The spindle assembly checkpoint (SAC) monitors chromosome attachment defects and the assembly of SAC proteins at kinetochores is essential for its activation, but the SAC disassembly process remains unknown. We found that deletion of a 14-3-3 protein, Bmh1, or hyper-activation of FEAR (Cdc14 Early Anaphase Release) allows premature SAC silencing in budding yeast, which depends on a kinetochore protein Fin1 that forms a complex with protein phosphatase PP1. Previous works suggest that FEAR-dependent Fin1 dephosphorylation promotes Bmh1-Fin1 dissociation, which enables kinetochore recruitment of Fin1-PP1. We found persistent kinetochore association of SAC protein Bub1 in fin1? mutants after anaphase entry. Therefore, we revealed a mechanism that clears SAC proteins from kinetochores. After anaphase entry, FEAR activation promotes kinetochore enrichment of Fin1-PP1, resulting in SAC disassembly at kinetochores. This mechanism is required for efficient SAC silencing after SAC being challenged, and untimely Fin1-kinetochore association causes premature SAC silencing and chromosome missegregation. Twit Text FOAVip Fin1-PP1 helps clear spindle assembly checkpoint protein Bub1 from kinetochores in anaphase ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26832405 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26832405 #FOAvip English Wikipedia <ref>{{Cite pmid|26832405}}</ref> Fin1-PP1 helps clear spindle assembly checkpoint protein Bub1 from kinetochores in anaphase #MMPMID26832405 Bokros M; Gravenmier C; Jin F; Richmond D; Wang Y Cell Rep 2016[Feb]; 14 (5): 1074-85 PMID26832405show ga The spindle assembly checkpoint (SAC) monitors chromosome attachment defects and the assembly of SAC proteins at kinetochores is essential for its activation, but the SAC disassembly process remains unknown. We found that deletion of a 14-3-3 protein, Bmh1, or hyper-activation of FEAR (Cdc14 Early Anaphase Release) allows premature SAC silencing in budding yeast, which depends on a kinetochore protein Fin1 that forms a complex with protein phosphatase PP1. Previous works suggest that FEAR-dependent Fin1 dephosphorylation promotes Bmh1-Fin1 dissociation, which enables kinetochore recruitment of Fin1-PP1. We found persistent kinetochore association of SAC protein Bub1 in fin1? mutants after anaphase entry. Therefore, we revealed a mechanism that clears SAC proteins from kinetochores. After anaphase entry, FEAR activation promotes kinetochore enrichment of Fin1-PP1, resulting in SAC disassembly at kinetochores. This mechanism is required for efficient SAC silencing after SAC being challenged, and untimely Fin1-kinetochore association causes premature SAC silencing and chromosome missegregation. äFin1-PP1 helps clear spindle assembly checkpoint protein Bub1 from kin(epmc).pdf DeepDyve Pubget Overpricing