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10.1152/physiol.00030.2015

http://scihub22266oqcxt.onion/10.1152/physiol.00030.2015
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C4747907!4747907!26525344
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suck abstract from ncbi


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pmid26525344      Physiology+(Bethesda) 2015 ; 30 (6): 449-59
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  • ASICs Mediate Pain and Inflammation in Musculoskeletal Diseases #MMPMID26525344
  • Abdelhamid RE; Sluka KA
  • Physiology (Bethesda) 2015[Nov]; 30 (6): 449-59 PMID26525344show ga
  • Chronic musculoskeletal pain is debilitating and affects ?20% of adults. Tissue acidosis is present in painful musculoskeletal diseases like rheumatoid arthritis. ASICs are located on skeletal muscle and joint nociceptors as well as on nonneuronal cells in the muscles and joints, where they mediate nociception. This review discusses the properties of different types of ASICs, factors affecting their pH sensitivity, and their role in musculoskeletal hyperalgesia and inflammation.
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