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http://scihub22266oqcxt.onion/ C4747403!4747403!26517809     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (38): 41237-57 Nephropedia Template TP {{tp|p=26517809|t=2015. Novel insights into Notum and glypicans regulation in colorectal cancer |pdf=|usr=}}{{26517809}} gab.com Text Novel insights into Notum and glypicans regulation in colorectal cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26517809 #FOAvip The connection between colorectal cancer (CRC) and Wnt signaling pathway activation is well known, but full elucidation of the underlying regulation of the Wnt/?-catenin pathway and its biological functions in CRC pathogenesis is still needed. Here, the azoxymethane/dextran sulfate sodium salt (AOM/DSS) murine model has been used as an experimental platform able to mimic human sporadic CRC development with predictable timing. We performed genome-wide expression profiling of AOM/DSS-induced tumors and normal colon mucosa to identify potential novel CRC biomarkers. Remarkably, the enhanced expression of Notum, a conserved feedback antagonist of Wnt, was observed in tumors along with alterations in Glypican-1 and Glypican-3 levels. These findings were confirmed in a set of human CRC samples. Here, we provide the first demonstration of significant changes in Notum and glypicans gene expression during CRC development and present evidence to suggest them as potential new biomarkers of CRC pathogenesis. Twit Text FOAVip Novel insights into Notum and glypicans regulation in colorectal cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26517809 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26517809 #FOAvip English Wikipedia <ref>{{Cite pmid|26517809}}</ref> Novel insights into Notum and glypicans regulation in colorectal cancer #MMPMID26517809 De Robertis M; Arigoni M; Loiacono L; Riccardo F; Calogero RA; Feodorova Y; Tashkova D; Belovejdov V; Sarafian V; Cavallo F; Signori E Oncotarget 2015[Dec]; 6 (38): 41237-57 PMID26517809show ga The connection between colorectal cancer (CRC) and Wnt signaling pathway activation is well known, but full elucidation of the underlying regulation of the Wnt/?-catenin pathway and its biological functions in CRC pathogenesis is still needed. Here, the azoxymethane/dextran sulfate sodium salt (AOM/DSS) murine model has been used as an experimental platform able to mimic human sporadic CRC development with predictable timing. We performed genome-wide expression profiling of AOM/DSS-induced tumors and normal colon mucosa to identify potential novel CRC biomarkers. Remarkably, the enhanced expression of Notum, a conserved feedback antagonist of Wnt, was observed in tumors along with alterations in Glypican-1 and Glypican-3 levels. These findings were confirmed in a set of human CRC samples. Here, we provide the first demonstration of significant changes in Notum and glypicans gene expression during CRC development and present evidence to suggest them as potential new biomarkers of CRC pathogenesis. äNovel insights into Notum and glypicans regulation in colorectal cance(epmc).pdf DeepDyve Pubget Overpricing