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http://scihub22266oqcxt.onion/ C4747377!4747377!26517513     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (38): 40907-19 Nephropedia Template TP {{tp|p=26517513|t=2015. Disulfiram inhibits TGF-?-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-?B/Snail pathway |pdf=|usr=}}{{26517513}} gab.com Text Disulfiram inhibits TGF- -induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF- B/Snail pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26517513 #FOAvip Disulfiram (DSF), an anti-alcoholism drug, has been reported as an inhibitor of NF-?B. NF-?B is involved in epithelial-mesenchymal transition (EMT) and self-renewal of breast cancer stem cells (CSCs). In this study, we treated MCF-7 and MDA-MB-231 breast cancer cells with TGF-? to induce EMT and cancer stem-like features and studied whether DSF can reverse this process. We found that DSF inhibited TGF-? induced EMT in breast cancer cells in a dose-dependent manner. Also, DSF inhibited EMT-associated stem-like features, migration and invasion of tumor cells as well as tumor growth in xenograft model. The activation of NF-?B was linked with EMT and stem-like cells. We conclude that DSF can suppress NF-?B activity and downregulate ERK/NF-?B/Snail pathway, leading to reverse EMT and stem-like features. Our data suggest that DSF inhibits EMT and stem-like properties in breast cancer cells associated with inhibition of the ERK/NF-?B/Snail pathway. Twit Text FOAVip Disulfiram inhibits TGF- -induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF- B/Snail pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26517513 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26517513 #FOAvip English Wikipedia <ref>{{Cite pmid|26517513}}</ref> Disulfiram inhibits TGF-?-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-?B/Snail pathway #MMPMID26517513 Han D; Wu G; Chang C; Zhu F; Xiao Y; Li Q; Zhang T; Zhang L Oncotarget 2015[Dec]; 6 (38): 40907-19 PMID26517513show ga Disulfiram (DSF), an anti-alcoholism drug, has been reported as an inhibitor of NF-?B. NF-?B is involved in epithelial-mesenchymal transition (EMT) and self-renewal of breast cancer stem cells (CSCs). In this study, we treated MCF-7 and MDA-MB-231 breast cancer cells with TGF-? to induce EMT and cancer stem-like features and studied whether DSF can reverse this process. We found that DSF inhibited TGF-? induced EMT in breast cancer cells in a dose-dependent manner. Also, DSF inhibited EMT-associated stem-like features, migration and invasion of tumor cells as well as tumor growth in xenograft model. The activation of NF-?B was linked with EMT and stem-like cells. We conclude that DSF can suppress NF-?B activity and downregulate ERK/NF-?B/Snail pathway, leading to reverse EMT and stem-like features. Our data suggest that DSF inhibits EMT and stem-like properties in breast cancer cells associated with inhibition of the ERK/NF-?B/Snail pathway. äDisulfiram inhibits TGF-?-induced epithelial-mesenchymal transition an(epmc).pdf DeepDyve Pubget Overpricing