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10.18632/oncotarget.5723 http://scihub22266oqcxt.onion/10.18632/oncotarget.5723 C4747377!4747377 !26517513     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26517513 &cmd=llinks): Failed to open stream: HTTP request failed! 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Disulfiram inhibits TGF-?-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-?B/Snail pathway |pdf=|usr=}}{{26517513 }} gab.com Text Disulfiram inhibits TGF- -induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF- B/Snail pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26517513 #FOAvip Disulfiram (DSF), an anti-alcoholism drug, has been reported as an inhibitor of NF-?B. NF-?B is involved in epithelial-mesenchymal transition (EMT) and self-renewal of breast cancer stem cells (CSCs). In this study, we treated MCF-7 and MDA-MB-231 breast cancer cells with TGF-? to induce EMT and cancer stem-like features and studied whether DSF can reverse this process. We found that DSF inhibited TGF-? induced EMT in breast cancer cells in a dose-dependent manner. Also, DSF inhibited EMT-associated stem-like features, migration and invasion of tumor cells as well as tumor growth in xenograft model. The activation of NF-?B was linked with EMT and stem-like cells. We conclude that DSF can suppress NF-?B activity and downregulate ERK/NF-?B/Snail pathway, leading to reverse EMT and stem-like features. Our data suggest that DSF inhibits EMT and stem-like properties in breast cancer cells associated with inhibition of the ERK/NF-?B/Snail pathway. Twit Text FOAVip Disulfiram inhibits TGF- -induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF- B/Snail pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26517513 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26517513 #FOAvip English Wikipedia <ref>{{Cite pmid|26517513 }}</ref> Disulfiram inhibits TGF-?-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-?B/Snail pathway #MMPMID26517513 Han D ; Wu G ; Chang C ; Zhu F ; Xiao Y ; Li Q ; Zhang T ; Zhang L Oncotarget 2015[Dec]; 6 (38 ): 40907-19 PMID26517513 show ga Disulfiram (DSF), an anti-alcoholism drug, has been reported as an inhibitor of NF-?B. NF-?B is involved in epithelial-mesenchymal transition (EMT) and self-renewal of breast cancer stem cells (CSCs). In this study, we treated MCF-7 and MDA-MB-231 breast cancer cells with TGF-? to induce EMT and cancer stem-like features and studied whether DSF can reverse this process. We found that DSF inhibited TGF-? induced EMT in breast cancer cells in a dose-dependent manner. Also, DSF inhibited EMT-associated stem-like features, migration and invasion of tumor cells as well as tumor growth in xenograft model. The activation of NF-?B was linked with EMT and stem-like cells. We conclude that DSF can suppress NF-?B activity and downregulate ERK/NF-?B/Snail pathway, leading to reverse EMT and stem-like features. Our data suggest that DSF inhibits EMT and stem-like properties in breast cancer cells associated with inhibition of the ERK/NF-?B/Snail pathway. |Alcohol Deterrents/pharmacology [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Blotting, Western [MESH] |Breast Neoplasms/etiology/metabolism/pathology/*prevention & control [MESH] |Cell Cycle/drug effects [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Disulfiram/*pharmacology [MESH] |Electrophoretic Mobility Shift Assay [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Female [MESH] |Fluorescent Antibody Technique [MESH] |Humans [MESH] |Immunoenzyme Techniques [MESH] |MAP Kinase Signaling System/*drug effects [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |NF-kappa B/*metabolism [MESH] |Neoplastic Stem Cells/*drug effects/metabolism/pathology [MESH] |Snail Family Transcription Factors [MESH] |Transcription Factors/*metabolism [MESH] |Transforming Growth Factor beta/*pharmacology [MESH] |Tumor Cells, Cultured [MESH]Disulfiram inhibits TGF-?-induced epithelial-mesenchymal transition an(epmc).pdf DeepDyve Pubget Overpricing