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10.18632/oncotarget.6149 http://scihub22266oqcxt.onion/10.18632/oncotarget.6149 C4747181!4747181 !26497679     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26497679 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (39 ): 41679-91 Nephropedia Template TP {{tp|p=26497679 |t=2015. Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-?B pathway |pdf=|usr=}}{{26497679 }} gab.com Text Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF- B pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26497679 #FOAvip The main characteristic of cancers, including breast cancer, is the ability of cancer cells to proliferate uncontrollably. However, the underlying mechanisms of cancer cell proliferation, especially those regulated by the RNA binding protein tristetraprolin (TTP), are not completely understood. In this study, we found that TTP inhibits cell proliferation in vitro and suppresses tumor growth in vivo through inducing cell cycle arrest at the S phase. Our studies demonstrate that TTP inhibits c-Jun expression through the C-terminal Zn finger and therefore increases Wee1 expression, a regulatory molecule which controls cell cycle transition from the S to the G2 phase. In contrast to the well-known function of TTP in regulating mRNA stability, TTP inhibits c-Jun expression at the level of transcription by selectively blocking NF-?B p65 nuclear translocation. Reconstitution of NF-?B p65 completely abolishes the inhibition of c-Jun transcription by TTP. Moreover, reconstitution of c-Jun in TTP-expressing breast tumor cells diminishes Wee1 overexpression and promotes cell proliferation. Our results indicate that TTP suppresses c-Jun expression that results in Wee1 induction which causes cell cycle arrest at the S phase and inhibition of cell proliferation. Our study provides a new pathway for TTP function as a tumor suppressor which could be targeted in tumor treatment. Twit Text FOAVip Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF- B pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26497679 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26497679 #FOAvip English Wikipedia <ref>{{Cite pmid|26497679 }}</ref> Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-?B pathway #MMPMID26497679 Xu L ; Ning H ; Gu L ; Wang Q ; Lu W ; Peng H ; Cui W ; Ying B ; Ross CR ; Wilson GM ; Wei L ; Wold WS ; Liu J Oncotarget 2015[Dec]; 6 (39 ): 41679-91 PMID26497679 show ga The main characteristic of cancers, including breast cancer, is the ability of cancer cells to proliferate uncontrollably. However, the underlying mechanisms of cancer cell proliferation, especially those regulated by the RNA binding protein tristetraprolin (TTP), are not completely understood. In this study, we found that TTP inhibits cell proliferation in vitro and suppresses tumor growth in vivo through inducing cell cycle arrest at the S phase. Our studies demonstrate that TTP inhibits c-Jun expression through the C-terminal Zn finger and therefore increases Wee1 expression, a regulatory molecule which controls cell cycle transition from the S to the G2 phase. In contrast to the well-known function of TTP in regulating mRNA stability, TTP inhibits c-Jun expression at the level of transcription by selectively blocking NF-?B p65 nuclear translocation. Reconstitution of NF-?B p65 completely abolishes the inhibition of c-Jun transcription by TTP. Moreover, reconstitution of c-Jun in TTP-expressing breast tumor cells diminishes Wee1 overexpression and promotes cell proliferation. Our results indicate that TTP suppresses c-Jun expression that results in Wee1 induction which causes cell cycle arrest at the S phase and inhibition of cell proliferation. Our study provides a new pathway for TTP function as a tumor suppressor which could be targeted in tumor treatment. |*S Phase Cell Cycle Checkpoints [MESH] |Animals [MESH] |Breast Neoplasms/genetics/*metabolism/pathology [MESH] |Cell Cycle Proteins/genetics/metabolism [MESH] |Cell Proliferation [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |HEK293 Cells [MESH] |Heterografts [MESH] |Humans [MESH] |MCF-7 Cells [MESH] |Mice [MESH] |Nuclear Proteins/genetics/metabolism [MESH] |Protein-Tyrosine Kinases/genetics/metabolism [MESH] |Proto-Oncogene Proteins c-jun/genetics/*metabolism [MESH] |Signal Transduction [MESH] |Time Factors [MESH] |Transcription Factor AP-1/genetics/*metabolism [MESH] |Transcription Factor RelA/genetics/*metabolism [MESH] |Transcription, Genetic [MESH] |Transfection [MESH] |Tristetraprolin/genetics/*metabolism [MESH]Tristetraprolin induces cell cycle arrest in breast tumor cells throug(epmc).pdf DeepDyve Pubget Overpricing