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10.1093/rheumatology/keu469 http://scihub22266oqcxt.onion/10.1093/rheumatology/keu469 C4746430!4746430!25539828     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25539828&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Rheumatology+(Oxford) 2016 ; 55 (3): 391-402 Nephropedia Template TP {{tp|p=25539828|t=2016. Gene, environment, microbiome and mucosal immune tolerance in rheumatoid arthritis |pdf=|usr=}}{{25539828}} gab.com Text Gene, environment, microbiome and mucosal immune tolerance in rheumatoid arthritis JO: Rheumatology (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=25539828 #FOAvip RA is a complex multifactorial chronic disease that transitions through several stages. Multiple studies now support that there is a prolonged phase in early RA development during which there is serum elevation of RA-related autoantibodies including RF and ACPAs in the absence of clinically evident synovitis. This suggests that RA pathogenesis might originate in an extra-articular location, which we hypothesize is a mucosal site. In discussing this hypothesis, we will present herein the current understanding of mucosal immunology, including a discussion about the generation of autoimmune responses at these surfaces. We will also examine how other factors such as genes, microbes and other environmental toxins (including tobacco smoke) could influence the triggering of autoimmunity at mucosal sites and eventually systemic organ disease. We will also propose a research agenda to improve our understanding of the role of mucosal inflammation in the development of RA. Twit Text FOAVip Gene, environment, microbiome and mucosal immune tolerance in rheumatoid arthritis ????Rheumatology (Oxford) http://www.kidney.de/pget.php?&tw=1&pmid=25539828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25539828 #FOAvip English Wikipedia <ref>{{Cite pmid|25539828}}</ref> Gene, environment, microbiome and mucosal immune tolerance in rheumatoid arthritis #MMPMID25539828 Catrina AI; Deane KD; Scher JU Rheumatology (Oxford) 2016[Mar]; 55 (3): 391-402 PMID25539828show ga RA is a complex multifactorial chronic disease that transitions through several stages. Multiple studies now support that there is a prolonged phase in early RA development during which there is serum elevation of RA-related autoantibodies including RF and ACPAs in the absence of clinically evident synovitis. This suggests that RA pathogenesis might originate in an extra-articular location, which we hypothesize is a mucosal site. In discussing this hypothesis, we will present herein the current understanding of mucosal immunology, including a discussion about the generation of autoimmune responses at these surfaces. We will also examine how other factors such as genes, microbes and other environmental toxins (including tobacco smoke) could influence the triggering of autoimmunity at mucosal sites and eventually systemic organ disease. We will also propose a research agenda to improve our understanding of the role of mucosal inflammation in the development of RA. äGene, environment, microbiome and mucosal immune tolerance in rheumato(epmc).pdf DeepDyve Pubget Overpricing