Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26425906
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Health+Phys
2015 ; 109
(5
): 466-78
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
A MALDI-MSI Approach to the Characterization of Radiation-Induced Lung Injury and
Medical Countermeasure Development
#MMPMID26425906
Carter CL
; Jones JW
; Barrow K
; Kieta K
; Taylor-Howell C
; Kearney S
; Smith CP
; Gibbs A
; Farese AM
; MacVittie TJ
; Kane MA
Health Phys
2015[Nov]; 109
(5
): 466-78
PMID26425906
show ga
Radiation-induced lung injury is highly complex and characterized by multiple
pathologies, which occur over time and sporadically throughout the lung. This
complexity makes biomarker investigations and medical countermeasure screenings
challenging. Matrix-assisted laser desorption/ionization mass spectrometry
imaging (MALDI-MSI) has the ability to resolve differences spatially in molecular
profiles within the lung following radiation exposure and can aid in biomarker
identification and pharmaceutical efficacy investigations. MALDI-MSI was applied
to the investigation of a whole-thorax lung irradiation model in non-human
primates (NHP) for lipidomic analysis and medical countermeasure distribution.
|Animals
[MESH]
|Biomarkers/analysis
[MESH]
|Dose-Response Relationship, Drug
[MESH]
|Lipids/*analysis
[MESH]
|Lung Injury/diagnosis/*metabolism/*prevention & control
[MESH]
|Macaca mulatta
[MESH]
|Male
[MESH]
|Metalloporphyrins/administration & dosage
[MESH]
|Radiation Injuries/diagnosis/*metabolism/*prevention & control
[MESH]